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    VPS60 Vps60p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS60
    Official Full Name
    Vps60p
    Primary source
    SGD:S000002894
    Locus tag
    YDR486C
    See related
    AllianceGenome:SGD:S000002894; FungiDB:YDR486C; VEuPathDB:YDR486C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CHM5; MOS10
    Summary
    Involved in late endosome to vacuole transport via multivesicular body sorting pathway. Located in fungal-type vacuole membrane. Orthologous to human CHMP5 (charged multivesicular body protein 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS60 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1427431..1428120, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Vps52p Neighboring gene Vps72p Neighboring gene 3,4-dihydroxy-2-butanone-4-phosphate synthase RIB3 Neighboring gene dynein intermediate chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mos10 (Vps60) is required for normal filament maturation in Saccharomyces cerevisiae. Köhler JR. Mol Microbiol, 2003 Sep. PMID 12940986
    2. Characterization of Vta1p, a class E Vps protein in Saccharomyces cerevisiae. Shiflett SL, et al. J Biol Chem, 2004 Mar 19. PMID 14701806
    3. Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway. Yang Z, et al. J Biol Chem, 2012 Dec 21. PMID 23105107, Free PMC Article
    4. Structural basis of Vta1 function in the multivesicular body sorting pathway. Xiao J, et al. Dev Cell, 2008 Jan. PMID 18194651, Free PMC Article
    5. Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase. Pashkova N, et al. Mol Biol Cell, 2021 Dec 1. PMID 34586919, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.
      Title: Structural basis of molecular recognition between ESCRT-III-like protein Vps60 and AAA-ATPase regulator Vta1 in the multivesicular body pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in late endosome to vacuole transport via multivesicular body sorting pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle budding from membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in multivesicular body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vps60p
    NP_010774.4
    • Protein involved in late endosome to vacuole transport; cytoplasmic and vacuolar membrane protein; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1427431..1428120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180794.3 → NP_010774.4  TPA: Vps60p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010774.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTA9, Q03390
      UniProtKB/TrEMBL
      A6ZZ75, B3LFI0, B5VH14, C7GKS4, C8Z644, G2WBL5, N1PAL1
      Conserved Domains (1) summary
      pfam03357
      Location:19 → 181
      Snf7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03390.2

    Gene LinkOut

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