FBP1 fructose 1,6-bisphosphate 1-phosphatase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FBP1
Official Full Name: fructose 1,6-bisphosphate 1-phosphatase
Primary source: SGD:S000004369
Locus tag: YLR377C
See related: AllianceGenome:SGD:S000004369; FungiDB:YLR377C; VEuPathDB:YLR377C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ACN8
Summary: Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis and reactive oxygen species metabolic process. Located in cytosol and periplasmic space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FBP1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (873746..874792, complement)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Title: GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Hypothesized that decreased FBP1 mRNA level could be due to the effect of Maf1 on tgm silencing (tRNA gene mediated silencing).
Title: Maf1, repressor of tRNA transcription, is involved in the control of gluconeogenetic genes in Saccharomyces cerevisiae.
Cdc48(Ufd1-Npl4) complex and the ubiquitin receptors Dsk2 and Rad23 act between between polyubiquitination of FBPase and its degradation by the proteasome.
Title: The Cdc48-Ufd1-Npl4 complex is central in ubiquitin-proteasome triggered catabolite degradation of fructose-1,6-bisphosphatase.
fructose-1,6-bisphosphatase and malate dehydrogenase degradation is mediated by distinct proteolytic pathways and signaling events
Title: Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events.
Influences the connection between DNA damage, aging and oxidative stress through either direct signalling or an intricate adaptation in energy metabolism.
Title: Fructose-1,6-bisphosphatase mediates cellular responses to DNA damage and aging in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-25g9 (e-PCR)
- UniSTS:257475

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables fructose 1,6-bisphosphate 1-phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables fructose 1,6-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info
enables fructose 1,6-bisphosphate 1-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 1,6-bisphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fructose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in gluconeogenesis	IEA Inferred from Electronic Annotation more info
involved_in gluconeogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in periplasmic space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: fructose 1,6-bisphosphate 1-phosphatase

NP_013481.3

EC 3.1.3.11

Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

873746..874792 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182266.3 → NP_013481.3 TPA: fructose 1,6-bisphosphate 1-phosphatase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013481.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZ13, P09201

UniProtKB/TrEMBL

A7A1Q3, B5VNR4, C7GRW9, C8ZDY7, G2WJJ3, N1P043

Conserved Domains (1) summary

COG0158
Location:20 → 348

Fbp; Fructose-1,6-bisphosphatase [Carbohydrate transport and metabolism]