Fezf1 Fez family zinc finger 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fezf1provided by MGI
Official Full Name: Fez family zinc finger 1provided by MGI
Primary source: MGI:MGI:1920441
See related: Ensembl:ENSMUSG00000029697 AllianceGenome:MGI:1920441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fez; fez-like; Zfp312-like; 3110069A13Rik
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including cell dedifferentiation; regulation of DNA-templated transcription; and regulation of neurogenesis. Acts upstream of or within nervous system development and positive regulation of neuron differentiation. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including brain and nose. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 22 with or without anosmia. Orthologous to human FEZF1 (FEZ family zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in whole brain E14.5 (RPKM 3.0), CNS E11.5 (RPKM 2.7) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A3.1; 6 10.55 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (23245043..23250942, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (23245044..23250936, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcriptional repressor, Fezf1, is selectively expressed by post-mitotic starburst amacrine cells.
Title: Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch.
Fezf1 gene has been identified in the present study as a regulator of female sexual behavior in mice. Regulation of the female sexual behavior could be through the regulation of estrogen receptor alpha expression in the ventromedial nucleus of the hypothalamus, as the expression of this receptor was reduced in mice with downregulated Fezf1.
Title: Fezf1 is a novel regulator of female sex behavior in mice.
These results identify Fezf1 and Fezf2 as important regulators of olfactory system development and sensory neuron identity.
Title: Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity.
Fezf1 and Fezf2 control differentiation of neural stem cells by repressing Hes5 and, in turn, by derepressing neurogenin 2 in the forebrain.
Title: Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain.
These data indicate that Fezf1 is required for the penetration of olfactory axons through the CNS basal lamina before they innervate the olfactory bulb.
Title: Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.
Fez is involved in the axonal projection of olfactory sensory neurons.
Title: Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously.
These data indicate that Fez and Fezl repress the caudal diencephalon fate in the rostral diencephalon, and ZLI formation probably depends on Fez/Fezl-mediated formation of diencephalon subdivisions.
Title: Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

Fezf1 (e-PCR), detects polymorphism
- UniSTS:507946

NoName (e-PCR)
- UniSTS:235392

Fezf1 (e-PCR), detects polymorphism
- UniSTS:530686

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell dedifferentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neurogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in telencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: fez family zinc finger protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_028462.1 → NP_082738.1 fez family zinc finger protein 1

See identical proteins and their annotated locations for NP_082738.1

Status: VALIDATED

Source sequence(s)

AC153639, AK014242

Consensus CDS

CCDS51725.1

UniProtKB/Swiss-Prot

Q0VDQ9, Q9CXM3

Related

ENSMUSP00000031709.6, ENSMUST00000031709.7

Conserved Domains (4) summary

COG5048
Location:287 → 421

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:262 → 282

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:402 → 420

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:305 → 327

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

23245043..23250942 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006505175.5 → XP_006505238.1 fez family zinc finger protein 1 isoform X1

See identical proteins and their annotated locations for XP_006505238.1

UniProtKB/Swiss-Prot

Q0VDQ9, Q9CXM3

Conserved Domains (4) summary

COG5048
Location:287 → 421

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:262 → 282

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:402 → 420

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:305 → 327

zf-H2C2_2; Zinc-finger double domain