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    Naaladl2 N-acetylated alpha-linked acidic dipeptidase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 635702, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naaladl2provided by MGI
    Official Full Name
    N-acetylated alpha-linked acidic dipeptidase-like 2provided by MGI
    Primary source
    MGI:MGI:2685867
    See related
    Ensembl:ENSMUSG00000102758 AllianceGenome:MGI:2685867
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1021; EG635702; 2810043G22Rik
    Summary
    Acts upstream of or within response to bacterium. Predicted to be located in nucleoplasm. Is expressed in gut; olfactory epithelium; urinary system; vertebral axis musculature; and vibrissa. Orthologous to human NAALADL2 (N-acetylated alpha-linked acidic dipeptidase like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Naaladl2 in Genome Data Viewer
    Location:
    3 A3; 3 9.24 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (23852267..25198425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (23798103..25144149, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_07168 Neighboring gene STARR-seq mESC enhancer starr_07169 Neighboring gene STARR-seq mESC enhancer starr_07170 Neighboring gene STARR-seq mESC enhancer starr_07171 Neighboring gene spindlin family, member 3, pseudogene Neighboring gene STARR-seq mESC enhancer starr_07172 Neighboring gene STARR-seq mESC enhancer starr_07173 Neighboring gene STARR-seq mESC enhancer starr_07174 Neighboring gene STARR-seq mESC enhancer starr_07175 Neighboring gene STARR-seq mESC enhancer starr_07176 Neighboring gene STARR-seq mESC enhancer starr_07177 Neighboring gene STARR-seq mESC enhancer starr_07178 Neighboring gene STARR-seq mESC enhancer starr_07179 Neighboring gene STARR-seq mESC enhancer starr_07180 Neighboring gene STARR-seq mESC enhancer starr_07181 Neighboring gene RIKEN cDNA 4930412E21 gene Neighboring gene STARR-seq mESC enhancer starr_07182 Neighboring gene STARR-seq mESC enhancer starr_07183 Neighboring gene STARR-seq mESC enhancer starr_07184 Neighboring gene STARR-seq mESC enhancer starr_07185 Neighboring gene STARR-seq mESC enhancer starr_07186 Neighboring gene STARR-seq mESC enhancer starr_07187 Neighboring gene STARR-seq mESC enhancer starr_07188 Neighboring gene STARR-seq mESC enhancer starr_07189 Neighboring gene STARR-seq mESC enhancer starr_07190 Neighboring gene STARR-seq mESC enhancer starr_07191 Neighboring gene predicted gene, 42191 Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 5 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07192 Neighboring gene STARR-seq mESC enhancer starr_07193 Neighboring gene nuclear encoded tRNA leucine 1 (anticodon CAG) Neighboring gene ribosomal protein L27A pseudogene Neighboring gene predicted gene, 24704 Neighboring gene STARR-seq mESC enhancer starr_07194 Neighboring gene STARR-seq mESC enhancer starr_07195 Neighboring gene STARR-seq mESC enhancer starr_07196 Neighboring gene STARR-seq mESC enhancer starr_07197 Neighboring gene STARR-seq mESC enhancer starr_07198 Neighboring gene STARR-seq mESC enhancer starr_07200 Neighboring gene STARR-seq mESC enhancer starr_07202 Neighboring gene STARR-seq mESC enhancer starr_07203 Neighboring gene STARR-seq mESC enhancer starr_07204 Neighboring gene STARR-seq mESC enhancer starr_07205 Neighboring gene STARR-seq mESC enhancer starr_07206 Neighboring gene STARR-seq mESC enhancer starr_07207 Neighboring gene STARR-seq mESC enhancer starr_07208 Neighboring gene STARR-seq mESC enhancer starr_07209 Neighboring gene karyopherin (importin) alpha 2 pseudogene Neighboring gene neuroligin 1 Neighboring gene predicted gene 6197

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2
    NP_001313217.1
    XP_017175170.1
    XP_017175171.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001326288.1 → NP_001313217.1  inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

      Status: PROVISIONAL

      Source sequence(s)
      AC108797, AC114627, AC116697, AC123693, AC136702, AC139675, AC161866
      Consensus CDS
      CCDS84612.1
      UniProtKB/TrEMBL
      A0A0N4SUJ3
      Related
      ENSMUSP00000144706.2, ENSMUST00000203414.2
      Conserved Domains (3) summary
      pfam04253
      Location:676 → 781
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl10459
      Location:258 → 409
      Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
      cl14876
      Location:418 → 649
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      23852267..25198425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319681.3 → XP_017175170.1  inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 isoform X1

      Conserved Domains (3) summary
      cl28883
      Location:241 → 392
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      pfam04253
      Location:659 → 764
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:408 → 631
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    2. XM_017319682.2 → XP_017175171.1  inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2 isoform X2

      Conserved Domains (3) summary
      cl28883
      Location:27 → 123
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
      pfam04253
      Location:390 → 495
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:139 → 362
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
    Nucleotide Protein Strain
    Heading Accession and Version

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