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    Tm9sf5 transmembrane 9 superfamily member 5 [ Mus musculus (house mouse) ]

    Gene ID: 245423, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tm9sf5provided by MGI
    Official Full Name
    transmembrane 9 superfamily member 5provided by MGI
    Primary source
    MGI:MGI:2685210
    See related
    Ensembl:ENSMUSG00000079584 AllianceGenome:MGI:2685210
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm364
    Summary
    Acts upstream of or within several processes, including positive regulation of Notch signaling pathway; positive regulation of protein modification process; and protein localization to plasma membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 6.0) See more
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    Genomic context

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    See Tm9sf5 in Genome Data Viewer
    Location:
    X A6; X 31.71 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (56446127..56534133)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (57400767..57488773)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Rac/Cdc42 guanine nucleotide exchange factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E7690 Neighboring gene STARR-seq mESC enhancer starr_47212 Neighboring gene STARR-positive B cell enhancer ABC_E7691 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:54563182-54563369 Neighboring gene STARR-seq mESC enhancer starr_47213 Neighboring gene STARR-seq mESC enhancer starr_47214 Neighboring gene small nucleolar RNA, C/D box 61 Neighboring gene RNA binding motif protein, X chromosome Neighboring gene G protein-coupled receptor 101 Neighboring gene STARR-seq mESC enhancer starr_47215 Neighboring gene predicted gene 14630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation. Chen LJ, et al. Cell Death Differ, 2022 Feb. PMID 34635817, Free PMC Article
    2. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
      Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of protein kinase B activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mammalian oogenesis stage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein LOC245423
    Names
    transmembrane 9 superfamily

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128625.2 → NP_001122097.1  uncharacterized protein LOC245423

      See identical proteins and their annotated locations for NP_001122097.1

      Status: VALIDATED

      Source sequence(s)
      AK030183, AL672122
      Consensus CDS
      CCDS53076.1
      UniProtKB/TrEMBL
      A2AFI6
      Related
      ENSMUSP00000110373.3, ENSMUST00000114725.3
      Conserved Domains (1) summary
      pfam02990
      Location:84 → 626
      EMP70; Endomembrane protein 70

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      56446127..56534133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528008.2 → XP_006528071.1  uncharacterized protein LOC245423 isoform X1

      Conserved Domains (1) summary
      pfam02990
      Location:91 → 634
      EMP70; Endomembrane protein 70
    Nucleotide Protein Strain
    Heading Accession and Version

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