Samtor S-adenosylmethionine sensor upstream of mTORC1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Samtorprovided by MGI
Official Full Name: S-adenosylmethionine sensor upstream of mTORC1provided by MGI
Primary source: MGI:MGI:2141466
See related: Ensembl:ENSMUSG00000042742 AllianceGenome:MGI:2141466
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmt2; B630005N14Rik
Summary: Predicted to enable S-adenosyl-L-methionine binding activity. Predicted to be involved in cellular response to amino acid starvation; cellular response to methionine; and regulation of TORC1 signaling. Orthologous to human BMT2 (base methyltransferase of 25S rRNA 2 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 4.8), whole brain E14.5 (RPKM 4.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 A1; 6 5.69 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (13625674..13677965, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (13625675..13677966, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI666701 (e-PCR)
- UniSTS:165451

NoName (e-PCR)
- UniSTS:487615

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	ISO Inferred from Sequence Orthology more info
enables S-adenosyl-L-methionine binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to methionine	IEA Inferred from Electronic Annotation more info
involved_in cellular response to methionine	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of TORC1 signaling	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: S-adenosylmethionine sensor upstream of mTORC1

Names: UPF0532 protein C7orf60 homolog; base methyltransferase of 25S rRNA 2; probable methyltransferase BMT2 homolog; probable methyltransferase BTM2 homolog

NP_780521.2

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.