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    Mid1ip1 Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish)) [ Mus musculus (house mouse) ]

    Gene ID: 68041, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mid1ip1provided by MGI
    Official Full Name
    Mid1 interacting protein 1 (gastrulation specific G12-like (zebrafish))provided by MGI
    Primary source
    MGI:MGI:1915291
    See related
    Ensembl:ENSMUSG00000008035 AllianceGenome:MGI:1915291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S14R; Mig12; 3110038L01Rik
    Summary
    Enables identical protein binding activity. Involved in positive regulation of fatty acid biosynthetic process; positive regulation of ligase activity; and protein polymerization. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytosol; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; limb segment; and nervous system. Orthologous to human MID1IP1 (MID1 interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 87.4), lung adult (RPKM 68.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mid1ip1 in Genome Data Viewer
    Location:
    X A1.1; X 5.4 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (10583604..10585941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (10717365..10719702)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A pseudogene Neighboring gene calmodulin 2 pseudogene Neighboring gene predicted gene, 33984 Neighboring gene STARR-seq mESC enhancer starr_46722 Neighboring gene predicted gene, 39494

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation. Inoue J, et al. Mol Endocrinol, 2011 Jun. PMID 21474539, Free PMC Article
    2. Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate. Tsatsos NG, et al. Endocrinology, 2008 Oct. PMID 18556348, Free PMC Article
    3. Overlapping roles of the glucose-responsive genes, S14 and S14R, in hepatic lipogenesis. Aipoalani DL, et al. Endocrinology, 2010 May. PMID 20233797, Free PMC Article
    4. Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules. Berti C, et al. BMC Cell Biol, 2004 Feb 29. PMID 15070402, Free PMC Article
    5. Crystal structure of Spot 14, a modulator of fatty acid synthesis. Colbert CL, et al. Proc Natl Acad Sci U S A, 2010 Nov 2. PMID 20952656, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIG12 is a mediator for stimulation of lipogenesis by LXR activation in the liver
      Title: Identification of MIG12 as a mediator for stimulation of lipogenesis by LXR activation.
    2. the S14-R protein is a compensatory factor, at least partially responsible for the normal liver lipogenesis observed in the S14 null mouse
      Title: Hepatic expression of the SPOT 14 (S14) paralog S14-related (Mid1 interacting protein) is regulated by dietary carbohydrate.
    3. Mig12 is expressed in the embryonic ventral midline and co-operates with Mid1 to stabilize microtubules
      Title: Mig12, a novel Opitz syndrome gene product partner, is expressed in the embryonic ventral midline and co-operates with Mid1 to bundle and stabilize microtubules.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of microtubule depolymerization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of lipid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lipid biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mid1-interacting protein 1
    Names
    gastrulation-specific G12-like protein
    mid1-interacting G12-like protein
    protein STRAIT11499 homolog
    spot 14-R
    spot 14-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166635.1 → NP_001160107.1  mid1-interacting protein 1

      See identical proteins and their annotated locations for NP_001160107.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL671335
      Consensus CDS
      CCDS30018.1
      UniProtKB/Swiss-Prot
      Q8BHT5, Q9CQ20
      UniProtKB/TrEMBL
      Q4FK31
      Related
      ENSMUSP00000111186.2, ENSMUST00000115524.8
      Conserved Domains (1) summary
      pfam07084
      Location:3 → 176
      Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

    2. NM_026524.4 → NP_080800.1  mid1-interacting protein 1

      See identical proteins and their annotated locations for NP_080800.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL671335
      Consensus CDS
      CCDS30018.1
      UniProtKB/Swiss-Prot
      Q8BHT5, Q9CQ20
      UniProtKB/TrEMBL
      Q4FK31
      Related
      ENSMUSP00000008179.7, ENSMUST00000008179.7
      Conserved Domains (1) summary
      pfam07084
      Location:3 → 176
      Spot_14; Thyroid hormone-inducible hepatic protein Spot 14

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      10583604..10585941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ20.1 GenPept UniProtKB/Swiss-Prot:Q9CQ20

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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