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    Bik BCL2-interacting killer [ Mus musculus (house mouse) ]

    Gene ID: 12124, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Bikprovided by MGI
    Official Full Name
    BCL2-interacting killerprovided by MGI
    Primary source
    MGI:MGI:1206591
    See related
    Ensembl:ENSMUSG00000016758 AllianceGenome:MGI:1206591
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Blk; Nbk; Biklk
    Summary
    Predicted to enable BH domain binding activity. Acts upstream of or within apoptotic mitochondrial changes; male gonad development; and spermatogenesis. Located in mitochondrial envelope. Is expressed in several structures, including genitourinary system; heart; liver; and lung. Human ortholog(s) of this gene implicated in ataxia telangiectasia; breast cancer; colon cancer; and prostate cancer. Orthologous to human BIK (BCL2 interacting killer). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 4.3), colon adult (RPKM 3.3) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Bik in Genome Data Viewer
    Location:
    15 E1; 15 39.4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (83410992..83428836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (83526790..83544635)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52181 Neighboring gene tubulin tyrosine ligase-like 1 Neighboring gene predicted gene, 46495 Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) Neighboring gene translocator protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Bik promotes proteasomal degradation to control low-grade inflammation. Mebratu YA, et al. J Clin Invest, 2023 Dec 19. PMID 38113109, Free PMC Article
    2. BH3-only protein BIK induces caspase-independent cell death with autophagic features in Bcl-2 null cells. Rashmi R, et al. Oncogene, 2008 Feb 28. PMID 17873911, Free PMC Article
    3. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Xie X, et al. Cancer Cell, 2007 Jul. PMID 17613436
    4. Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer. Sher YP, et al. Mol Cancer Ther, 2011 Apr. PMID 21282355
    5. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Lang JY, et al. Cancer Cell, 2011 Sep 13. PMID 21907925, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Bik promotes proteasomal degradation to control low-grade inflammation.
      Title: Bik promotes proteasomal degradation to control low-grade inflammation.
    2. Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females.
      Title: Reduced Bik expression drives low-grade airway inflammation and increased risk for COPD in females.
    3. Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice.
      Title: Independent role of caspases and Bik in augmenting influenza A virus replication in airway epithelial cells and mice.
    4. Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins.
      Title: Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins.
    5. Bcl-2 interacting killer (Bik) decreases airway epithelial hyperplasia via apoptosis mediated by calcium release from the endoplasmic reticulum (ER), but the mechanism is unclear. Here the authors show that Bik promotes Bak enrichment at the ER to tether mitochondria for efficient calcium transfer.
      Title: Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.
    6. These studies suggest a link between Bik-mediated caspase activation and cleavage of viral proteins.
      Title: Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.
    7. OPN induces oxidative stress via the involvement of mitochondria and NOX-4. It may affect mitochondrial morphology and integrity, at least in part, via the involvement of BIK.
      Title: Osteopontin-stimulated apoptosis in cardiac myocytes involves oxidative stress and mitochondrial death pathway: role of a pro-apoptotic protein BIK.
    8. Findings identify novel cross talk between autophagy and apoptosis, wherein targeting SQSTM1/p62 converts cytoprotective autophagy to an inefficient form due to cargo loading failure, leading to NBK/Bik accumulation, which triggers apoptosis.
      Title: Targeting SQSTM1/p62 induces cargo loading failure and converts autophagy to apoptosis via NBK/Bik.
    9. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
      Title: Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik.
    10. The Bik protein, even in combination with Noxa, is not a potent suppressor of c-Myc-driven tumourigenesis or critical for chemotherapeutic drug-induced killing of Myc-driven tumours.
      Title: Neither loss of Bik alone, nor combined loss of Bik and Noxa, accelerate murine lymphoma development or render lymphoma cells resistant to DNA damaging drugs.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables BH domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic mitochondrial changes IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within apoptotic mitochondrial changes IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in male gonad development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within male gonad development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of cytochrome c from mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Bcl-2 family protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    bcl-2-interacting killer
    Names
    apoptosis inducer NBK
    bik-like killer protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007546.2 → NP_031572.1  bcl-2-interacting killer

      See identical proteins and their annotated locations for NP_031572.1

      Status: PROVISIONAL

      Source sequence(s)
      AL583889
      Consensus CDS
      CCDS27703.1
      UniProtKB/Swiss-Prot
      O70337
      UniProtKB/TrEMBL
      A0A2R8W6U8
      Related
      ENSMUSP00000016902.4, ENSMUST00000016902.5
      Conserved Domains (1) summary
      pfam12201
      Location:1 → 149
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      83410992..83428836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520354.5 → XP_006520417.1  bcl-2-interacting killer isoform X2

      UniProtKB/TrEMBL
      Q99L97
      Conserved Domains (1) summary
      pfam12201
      Location:34 → 182
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing

    2. XM_006520355.3 → XP_006520418.1  bcl-2-interacting killer isoform X3

      See identical proteins and their annotated locations for XP_006520418.1

      UniProtKB/Swiss-Prot
      O70337
      UniProtKB/TrEMBL
      A0A2R8W6U8
      Related
      ENSMUSP00000155439.2, ENSMUST00000229165.2
      Conserved Domains (1) summary
      pfam12201
      Location:1 → 149
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing

    3. XM_006520356.2 → XP_006520419.1  bcl-2-interacting killer isoform X3

      See identical proteins and their annotated locations for XP_006520419.1

      UniProtKB/Swiss-Prot
      O70337
      UniProtKB/TrEMBL
      A0A2R8W6U8
      Conserved Domains (1) summary
      pfam12201
      Location:1 → 149
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing

    4. XM_006520353.4 → XP_006520416.1  bcl-2-interacting killer isoform X1

      Conserved Domains (1) summary
      pfam12201
      Location:60 → 208
      bcl-2I13; Bcl2-interacting killer, BH3-domain containing
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70337.1 GenPept UniProtKB/Swiss-Prot:O70337

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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