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    PRP21 Prp21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853227, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRP21
    Official Full Name
    Prp21p
    Primary source
    SGD:S000003739
    Locus tag
    YJL203W
    See related
    AllianceGenome:SGD:S000003739; FungiDB:YJL203W; VEuPathDB:YJL203W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SPP91
    Summary
    Enables RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2-type prespliceosome. Orthologous to human SF3A1 (splicing factor 3a subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRP21 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (53341..54183)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Nce101p Neighboring gene Rcy1p Neighboring gene Ecm25p Neighboring gene aconitate hydratase ACO2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome. Arenas JE, et al. Proc Natl Acad Sci U S A, 1993 Jul 15. PMID 8341697, Free PMC Article
    2. A novel gene, spp91-1, suppresses the splicing defect and the pre-mRNA nuclear export in the prp9-1 mutant. Chapon C, et al. EMBO J, 1992 Sep. PMID 1505518, Free PMC Article
    3. Interactions between PRP9 and SPP91 splicing factors identify a protein complex required in prespliceosome assembly. Legrain P, et al. Genes Dev, 1993 Jul. PMID 8330742
    4. An extragenic suppressor of prp24-1 defines genetic interaction between PRP24 and PRP21 gene products of Saccharomyces cerevisiae. Vaidya VC, et al. Mol Gen Genet, 1996 Feb 25. PMID 8602141
    5. In vitro studies of the Prp9.Prp11.Prp21 complex indicate a pathway for U2 small nuclear ribonucleoprotein activation. Wiest DK, et al. J Biol Chem, 1996 Dec 27. PMID 8969185

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of U2-type prespliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type prespliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Prp21p
    NP_012332.1
    • Subunit of the SF3a splicing factor complex; required for spliceosome assembly

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      53341..54183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181636.1 → NP_012332.1  TPA: Prp21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012332.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVZ1, P32524, Q6Q5G7
      UniProtKB/TrEMBL
      G2WGH7, N1P0Y1
      Conserved Domains (1) summary
      smart00648
      Location:9 → 55
      SWAP; Suppressor-of-White-APricot splicing regulator
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32524.1

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