Kif13b kinesin family member 13B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif13bprovided by MGI
Official Full Name: kinesin family member 13Bprovided by MGI
Primary source: MGI:MGI:1098265
See related: Ensembl:ENSMUSG00000060012 AllianceGenome:MGI:1098265
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GAKIN; 6030414C01; 5330429L19Rik; C130021D12Rik
Summary: Predicted to enable several functions, including 14-3-3 protein binding activity; ATP hydrolysis activity; and microtubule binding activity. Predicted to be involved in microtubule-based movement and regulation of axonogenesis. Predicted to be located in cytosol; microvillus; and paranode region of axon. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in cortical plate; dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human KIF13B (kinesin family member 13B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in colon adult (RPKM 13.2), cerebellum adult (RPKM 6.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.77 cM

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (64889633..65047067)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (64652492..64809618)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo.
Title: KIF13B-mediated VEGFR2 trafficking is essential for vascular leakage and metastasis in vivo.
Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.
Title: Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.
The carboxyl-terminal region of KIF13B containing the CAP-Gly domain is important for the LRP1-DLG1-KIF13B complex formation with implications in the regulation of metabolism, cell polarity, and development.
Title: LDL receptor related protein 1 requires the I(3) domain of discs-large homolog 1/DLG1 for interaction with the kinesin motor protein KIF13B.
Kif13b also negatively regulates Dlg1 stability in oligodendrocytes, in which Dlg1, in contrast to Schwann cells, enhances AKT activation and promotes myelination
Title: Kif13b Regulates PNS and CNS Myelination through the Dlg1 Scaffold.
KIF13B, working as a scaffold, recruits LRP1 to caveolae.
Title: KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2)
Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI429803 (e-PCR)
- UniSTS:165909

D5Ertd559e (e-PCR), detects polymorphism
- UniSTS:167446

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: kinesin-like protein KIF13B

Names: N-3 kinesin; kinesin 13B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081177.3 → NP_001074646.1 kinesin-like protein KIF13B

Status: VALIDATED

Source sequence(s)

AC105979, AC132602

Consensus CDS

CCDS36954.1

UniProtKB/TrEMBL

E9Q4K7

Related

ENSMUSP00000098041.5, ENSMUST00000100473.5

Conserved Domains (10) summary

smart00129
Location:6 → 360

KISc; Kinesin motor, catalytic domain. ATPase

COG1716
Location:459 → 573

FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1720 → 1783

CAP_GLY; CAP-Gly domain

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1220 → 1278

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

cl14603
Location:888 → 952

C2; C2 domain

cl23748
Location:1073 → 1143

DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

64889633..65047067

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518619.5 → XP_006518682.1 kinesin-like protein KIF13B isoform X1

UniProtKB/TrEMBL

A0A286YCV9

Related

ENSMUSP00000153168.2, ENSMUST00000224503.2

Conserved Domains (10) summary

PHA03247
Location:1423 → 1659

PHA03247; large tegument protein UL36; Provisional

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1724 → 1787

CAP_GLY; CAP-Gly domain

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1220 → 1278

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

pfam12128
Location:544 → 772

DUF3584; Protein of unknown function (DUF3584)

cl14603
Location:888 → 952

C2; C2 domain

cl23748
Location:1073 → 1143

DUF3585; Protein of unknown function (DUF3585)
XM_006518620.5 → XP_006518683.1 kinesin-like protein KIF13B isoform X2

Conserved Domains (10) summary

PHA03247
Location:1423 → 1638

PHA03247; large tegument protein UL36; Provisional

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam01302
Location:1703 → 1766

CAP_GLY; CAP-Gly domain

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1220 → 1278

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

pfam12128
Location:544 → 772

DUF3584; Protein of unknown function (DUF3584)

cl14603
Location:888 → 952

C2; C2 domain

cl23748
Location:1073 → 1143

DUF3585; Protein of unknown function (DUF3585)
XM_006518622.4 → XP_006518685.1 kinesin-like protein KIF13B isoform X4

Conserved Domains (8) summary

cd00060
Location:447 → 544

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cd01365
Location:4 → 360

KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins

pfam12423
Location:756 → 802

KIF1B; Kinesin protein 1B

pfam12473
Location:1220 → 1278

DUF3694; Kinesin protein

pfam16183
Location:357 → 469

Kinesin_assoc; Kinesin-associated

pfam12128
Location:544 → 772

DUF3584; Protein of unknown function (DUF3584)

cl14603
Location:888 → 952

C2; C2 domain

cl23748
Location:1073 → 1143

DUF3585; Protein of unknown function (DUF3585)
XM_006518621.5 → XP_006518684.1 kinesin-like protein KIF13B isoform X3

Conserved Domains (10) summary

PHA03247
Location:1098 → 1334

PHA03247; large tegument protein UL36; Provisional

cd00060
Location:122 → 219

FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

cl22853
Location:1 → 35

Motor_domain; Myosin and Kinesin motor domain

pfam01302
Location:1399 → 1462

CAP_GLY; CAP-Gly domain

pfam12423
Location:431 → 477

KIF1B; Kinesin protein 1B

pfam12473
Location:895 → 953

DUF3694; Kinesin protein

pfam16183
Location:32 → 144

Kinesin_assoc; Kinesin-associated

pfam12128
Location:219 → 447

DUF3584; Protein of unknown function (DUF3584)

cl14603
Location:563 → 627

C2; C2 domain

cl23748
Location:748 → 818

DUF3585; Protein of unknown function (DUF3585)