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    RIM4 Rim4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIM4
    Official Full Name
    Rim4p
    Primary source
    SGD:S000001016
    Locus tag
    YHL024W
    See related
    AllianceGenome:SGD:S000001016; FungiDB:YHL024W; VEuPathDB:YHL024W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in premeiotic DNA replication; reciprocal meiotic recombination; and sporulation resulting in formation of a cellular spore. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIM4 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (56649..58790)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Snf6p Neighboring gene Npr3p Neighboring gene tRNA-His

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly and function of the amyloid-like translational repressor Rim4 is coupled with nutrient conditions. Ottoz DS, et al. EMBO J, 2023 Dec 1. PMID 37921330, Free PMC Article
    2. A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern. Berchowitz LE, et al. Genes Dev, 2013 Oct 1. PMID 24115771, Free PMC Article
    3. Autophagy of an Amyloid-like Translational Repressor Regulates Meiotic Exit. Wang F, et al. Dev Cell, 2020 Jan 27. PMID 31991104, Free PMC Article
    4. Meiotic Cells Counteract Programmed Retrotransposon Activation via RNA-Binding Translational Repressor Assemblies. Laureau R, et al. Dev Cell, 2021 Jan 11. PMID 33278343, Free PMC Article
    5. Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis. Berchowitz LE, et al. Cell, 2015 Oct 8. PMID 26411291, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Assembly and function of the amyloid-like translational repressor Rim4 is coupled with nutrient conditions.
      Title: Assembly and function of the amyloid-like translational repressor Rim4 is coupled with nutrient conditions.
    2. Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
      Title: Regulation of Rim4 distribution, function, and stability during meiosis by PKA, Cdc14, and 14-3-3 proteins.
    3. identify the protein kinase Ime2 to bring about Rim4 clearance via phosphorylation of Rim4's intrinsically disordered region
      Title: Phosphorylation-Mediated Clearance of Amyloid-like Assemblies in Meiosis.
    4. Rim4 forms amyloid-like aggregates and that it is the amyloid-like form of Rim4 that is the active, translationally repressive form of the protein; data further show that Rim4 aggregation is a developmentally regulated process; at the onset of meiosis II, Rim4 aggregates are abruptly degraded allowing translation to commence.
      Title: Regulated Formation of an Amyloid-like Translational Repressor Governs Gametogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in premeiotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sporulation resulting in formation of a cellular spore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rim4p
    NP_011839.1
    • Putative RNA-binding protein; involved in regulation of early and middle sporulation genes; forms amyloid-like aggregates under starvation that are active in translational repression

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      56649..58790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179104.1 → NP_011839.1  TPA: Rim4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011839.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKU4, E9P8V3, P38741
      UniProtKB/TrEMBL
      G2WF42, N1P9G0
      Conserved Domains (6) summary
      COG0724
      Location:1 → 191
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      TIGR01622
      Location:300 → 378
      SF-CC1; splicing factor, CC1-like family
      pfam14179
      Location:615 → 669
      YppG; YppG-like protein
      cd00590
      Location:176 → 242
      RRM_SF; RNA recognition motif (RRM) superfamily
      cd12453
      Location:91 → 176
      RRM1_RIM4_like; RNA recognition motif 1 (RRM1) found in yeast meiotic activator RIM4 and similar proteins
      cd12454
      Location:343 → 420
      RRM2_RIM4_like; RNA recognition motif 2 (RRM2) found in yeast meiotic activator RIM4 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38741.1

    Gene LinkOut

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