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    Pde1b phosphodiesterase 1B, Ca2+-calmodulin dependent [ Mus musculus (house mouse) ]

    Gene ID: 18574, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Pde1bprovided by MGI
    Official Full Name
    phosphodiesterase 1B, Ca2+-calmodulin dependentprovided by MGI
    Primary source
    MGI:MGI:97523
    See related
    Ensembl:ENSMUSG00000022489 AllianceGenome:MGI:97523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pde1b1
    Summary
    Predicted to enable calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Acts upstream of with a positive effect on dopamine catabolic process. Acts upstream of or within several processes, including response to amphetamine; serotonin metabolic process; and visual learning. Predicted to be located in cytosol. Predicted to be active in neuronal cell body. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skeleton. Orthologous to human PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 29.2), frontal lobe adult (RPKM 27.9) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pde1b in Genome Data Viewer
    Location:
    15 F3; 15 58.99 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (103411461..103438483)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (103503034..103530056)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene MARCKS-like 1, pseudogene 3 Neighboring gene gametocyte specific factor 2 Neighboring gene NCK associated protein 1 like Neighboring gene STARR-seq mESC enhancer starr_39886 Neighboring gene STARR-seq mESC enhancer starr_39888 Neighboring gene protein phosphatase 1, regulatory inhibitor subunit 1A Neighboring gene glycosylation dependent cell adhesion molecule 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of DNA encoding a calmodulin-dependent phosphodiesterase enriched in striatum. Polli JW, et al. Proc Natl Acad Sci U S A, 1992 Nov 15. PMID 1332068, Free PMC Article
    2. Genomic structure and chromosome location of the murine PDE1B phosphodiesterase gene. Reed TM, et al. Mamm Genome, 1998 Jul. PMID 9657856
    3. Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice. Hufgard JR, et al. Genes Brain Behav, 2017 Nov. PMID 28488329, Free PMC Article
    4. Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a. Hufgard JR, et al. Psychopharmacology (Berl), 2017 Jun. PMID 28337525
    5. Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning. Reed TM, et al. J Neurosci, 2002 Jun 15. PMID 12077213, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. New Floxed Pde1b x CreCMV global knockout (KO) mice demonstrate depression-like behavioral resistance separate from stress-related effects.
      Title: Phosphodiesterase-1b deletion confers depression-like behavioral resistance separate from stress-related effects in mice.
    2. Pde1b knock-out mice exhibited decreased tail suspension test and forced swim test immobilization; a model for depression.
      Title: Phosphodiesterase-1b (Pde1b) knockout mice are resistant to forced swim and tail suspension induced immobility and show upregulation of Pde10a.
    3. These results prove that the kinetic properties of PDE isoforms play a major role in determining intracellular cAMP signals in response to physiological elevation of [Ca2+]i.
      Title: Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+.
    4. The present studies demonstrate increased striatal dopamine turnover in PDE1B knockout mice associated with increased baseline motor activity and an exaggerated locomotor response to dopaminergic stimulants such as methamphetamine and amphetamine.
      Title: Behavioral and neurochemical characterization of mice deficient in the phosphodiesterase-1B (PDE1B) enzyme.
    5. Data suggest a role for PDE1B in locomotor responses to psychostimulants through modulation of DARPP32-dependent pathways; however, this modulation does not necessarily impact other behaviors, such as anxiety or learning.
      Title: Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice.
    6. knock-out mice exhibit locomotor hyperactivity in response to dopamine agonists and display impaired spatial learning
      Title: Phosphodiesterase 1B knock-out mice exhibit exaggerated locomotor hyperactivity and DARPP-32 phosphorylation in response to dopamine agonists and display impaired spatial learning.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3',5'-cGMP-inhibited cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cyclic-nucleotide phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to macrophage colony-stimulating factor stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to macrophage colony-stimulating factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect dopamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to amphetamine IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to amphetamine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within serotonin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    Names
    63 kDa Cam-PDE
    calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
    cam-PDE 1B
    phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa
    phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa
    NP_001272819.1
    NP_001344909.1
    NP_032826.1
    XP_030104267.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285890.1 → NP_001272819.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and contains an alternate 5' terminal exon compared to variant 1. The encoded protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC131721, AK004772, CV784321, DN173601
      Consensus CDS
      CCDS88861.1
      UniProtKB/TrEMBL
      A0A2I3BPC1, Q6PDS5
      Related
      ENSMUSP00000153722.2, ENSMUST00000227955.2
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 429
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_001357980.1 → NP_001344909.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and contains an alternate 5' terminal exon compared to variant 1. The encoded protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC131721
      UniProtKB/TrEMBL
      Q6PDS5
      Conserved Domains (2) summary
      pfam00233
      Location:202 → 427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:61 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    3. NM_008800.2 → NP_032826.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform 1

      See identical proteins and their annotated locations for NP_032826.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131721, BC058531, DN173601
      Consensus CDS
      CCDS27904.1
      UniProtKB/Swiss-Prot
      O35384, Q01065
      UniProtKB/TrEMBL
      Q6PDS5
      Related
      ENSMUSP00000023132.4, ENSMUST00000023132.5
      Conserved Domains (2) summary
      pfam00233
      Location:221 → 448
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:80 → 136
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      103411461..103438483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248407.1 → XP_030104267.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1

      UniProtKB/TrEMBL
      Q6PDS5, Q9DBS6
      Conserved Domains (2) summary
      pfam00233
      Location:181 → 408
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:40 → 96
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q01065.2 GenPept UniProtKB/Swiss-Prot:Q01065

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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