Ilkap integrin-linked kinase-associated serine/threonine phosphatase 2C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ilkapprovided by MGI
Official Full Name: integrin-linked kinase-associated serine/threonine phosphatase 2Cprovided by MGI
Primary source: MGI:MGI:1914694
See related: Ensembl:ENSMUSG00000026309 AllianceGenome:MGI:1914694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PP2C-DELTA; 0710007A14Rik; 1600009O09Rik
Summary: Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in regulation of nuclear cell cycle DNA replication and signal transduction. Predicted to be located in cytoplasm. Is expressed in central nervous system; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human ILKAP (ILK associated serine/threonine phosphatase). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 16.1), CNS E14 (RPKM 12.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.11 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91301568..91326566, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91373846..91398844, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PP2Cdelta, via dephosphorylation of ATM, suppresses DNA damage-induced BRCA1 phosphorylation.
Title: PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer.
These studies demonstrate the importance for keratinocyte proliferation of ILK regulation through changes in its subcellular localization, and establish ILKAP and CRM1 as pivotal modulators of ILK subcellular distribution and activity in these cells.
Title: Modulation of integrin-linked kinase nucleo-cytoplasmic shuttling by ILKAP and CRM1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI326893 (e-PCR)
- UniSTS:164122

Hes6 (e-PCR), detects polymorphism
- UniSTS:506971

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in regulation of nuclear cell cycle DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: integrin-linked kinase-associated serine/threonine phosphatase 2C

NP_001342081.1

EC 3.1.3.16

NP_075832.1

EC 3.1.3.16

XP_006529870.1

EC 3.1.3.16

XP_006529871.1

EC 3.1.3.16

XP_006529872.1

EC 3.1.3.16

XP_006529873.1

EC 3.1.3.16

XP_006529874.1

EC 3.1.3.16

XP_006529875.1

EC 3.1.3.16

XP_006529876.1

EC 3.1.3.16

XP_006529877.1

EC 3.1.3.16

XP_006529878.1

EC 3.1.3.16

XP_030098240.1

EC 3.1.3.16

XP_030098245.1

EC 3.1.3.16

XP_030098247.1

EC 3.1.3.16

XP_030098259.1

EC 3.1.3.16

XP_030098261.1

EC 3.1.3.16

XP_030098264.1

EC 3.1.3.16

XP_030098265.1

EC 3.1.3.16

XP_030098270.1

EC 3.1.3.16

XP_030098273.1

EC 3.1.3.16

XP_030098275.1

EC 3.1.3.16

XP_030098278.1

EC 3.1.3.16

XP_030098281.1

EC 3.1.3.16

XP_030098282.1

EC 3.1.3.16

XP_030098284.1

EC 3.1.3.16

XP_030098286.1

EC 3.1.3.16

XP_036009024.1

EC 3.1.3.16

XP_036009025.1

EC 3.1.3.16

XP_036009026.1

EC 3.1.3.16

XP_036009027.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355152.1 → NP_001342081.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform 2

Status: VALIDATED

Source sequence(s)

AC110510

Conserved Domains (1) summary

cd00143
Location:1 → 226

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_023343.3 → NP_075832.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform 1

Status: VALIDATED

Source sequence(s)

AC110510

Consensus CDS

CCDS15162.1

UniProtKB/Swiss-Prot

Q05CC3, Q8R0F6

Related

ENSMUSP00000027534.7, ENSMUST00000027534.13

Conserved Domains (1) summary

cd00143
Location:108 → 390

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

91301568..91326566 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242380.2 → XP_030098240.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X7

Conserved Domains (1) summary

cd00143
Location:102 → 345

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529810.5 → XP_006529873.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X5

Conserved Domains (1) summary

cd00143
Location:108 → 351

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529807.5 → XP_006529870.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X1

Conserved Domains (1) summary

cd00143
Location:108 → 346

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242387.2 → XP_030098247.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X11

Conserved Domains (1) summary

cd00143
Location:86 → 259

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242415.2 → XP_030098275.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X14

Conserved Domains (1) summary

cd00143
Location:1 → 231

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242418.2 → XP_030098278.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X14

Conserved Domains (1) summary

cd00143
Location:1 → 231

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242413.2 → XP_030098273.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X13

Conserved Domains (1) summary

cd00143
Location:1 → 226

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242421.2 → XP_030098281.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X14

Conserved Domains (1) summary

cd00143
Location:1 → 231

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_036153131.1 → XP_036009024.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X9

Conserved Domains (1) summary

cd00143
Location:102 → 314

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529808.5 → XP_006529871.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X2

Conserved Domains (1) summary

cd00143
Location:102 → 384

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529813.5 → XP_006529876.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X8

Conserved Domains (1) summary

cd00143
Location:108 → 320

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242385.2 → XP_030098245.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X10

Conserved Domains (1) summary

cd00143
Location:86 → 298

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529812.5 → XP_006529875.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X6

Conserved Domains (1) summary

cd00143
Location:80 → 362

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529811.5 → XP_006529874.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X4

Conserved Domains (1) summary

cd00143
Location:86 → 368

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529815.4 → XP_006529878.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242422.2 → XP_030098282.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15

Conserved Domains (1) summary

cd00143
Location:1 → 200

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242424.2 → XP_030098284.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15

Conserved Domains (1) summary

cd00143
Location:1 → 200

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242426.2 → XP_030098286.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X15

Conserved Domains (1) summary

cd00143
Location:1 → 200

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242410.2 → XP_030098270.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242401.2 → XP_030098261.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242399.2 → XP_030098259.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529814.4 → XP_006529877.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_036153132.1 → XP_036009025.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242405.2 → XP_030098265.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_030242404.2 → XP_030098264.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_036153133.1 → XP_036009026.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_036153134.1 → XP_036009027.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X12

Conserved Domains (1) summary

cd00143
Location:1 → 270

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
XM_006529809.5 → XP_006529872.1 integrin-linked kinase-associated serine/threonine phosphatase 2C isoform X3

Conserved Domains (1) summary

cd00143
Location:100 → 382

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...