Camsap2 calmodulin regulated spectrin-associated protein family, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Camsap2provided by MGI
Official Full Name: calmodulin regulated spectrin-associated protein family, member 2provided by MGI
Primary source: MGI:MGI:1922434
See related: Ensembl:ENSMUSG00000041570 AllianceGenome:MGI:1922434
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Camsap1l1; mKIAA1078; 1600013L13Rik; 4930541M15Rik
Summary: Enables microtubule minus-end binding activity. Involved in regulation of organelle organization. Located in ciliary basal body and microtubule minus-end. Is expressed in jaw bone; liver; lung; nervous system; and neural retina. Orthologous to human CAMSAP2 (calmodulin regulated spectrin associated protein family member 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 12.4), whole brain E14.5 (RPKM 11.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 59.61 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (136195861..136273855, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (136268123..136346117, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells.
Title: Deficiency of CAMSAP2 impairs olfaction and the morphogenesis of mitral cells.
[High expression of CAMSAP2 promotes invasion and metastasis of gastric cancer cells by upregulating TGF-beta signaling].
Title: [High expression of CAMSAP2 promotes invasion and metastasis of gastric cancer cells by upregulating TGF-β signaling].
CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
Title: CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway.
CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
Title: CAMSAPs organize an acentrosomal microtubule network from basal varicosities in radial glial cells.
CAMSAP2 and -3 work together to maintain noncentrosomal microtubules in epithelial cells, suppressing the microtubule-organizing ability of the centrosome.
Title: Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D1Mit197 (e-PCR), detects polymorphism
- UniSTS:128535

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microtubule minus-end binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule minus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule minus-end binding	ISO Inferred from Sequence Orthology more info
enables microtubule minus-end binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	ISO Inferred from Sequence Orthology more info
involved_in axon development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of Golgi organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of organelle organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of organelle organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
colocalizes_with Golgi apparatus	ISO Inferred from Sequence Orthology more info
colocalizes_with Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule end	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule minus-end	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule minus-end	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with microtubule minus-end	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calmodulin-regulated spectrin-associated protein 2

Names: calmodulin-regulated spectrin-associated protein 1-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347109.1 → NP_001334038.1 calmodulin-regulated spectrin-associated protein 2 isoform 2

Status: VALIDATED

Source sequence(s)

AC120875, AC124550

Consensus CDS

CCDS83598.1

UniProtKB/TrEMBL

A0A0A6YY67, B2RRE3

Related

ENSMUSP00000142299.2, ENSMUST00000192314.2
NM_001347110.1 → NP_001334039.1 calmodulin-regulated spectrin-associated protein 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC120875, AC124550

Consensus CDS

CCDS83597.1

UniProtKB/Swiss-Prot

B7ZNI4, Q80TK8, Q8C1B1, Q8C4J5

UniProtKB/TrEMBL

B2RRE3

Related

ENSMUSP00000142166.2, ENSMUST00000192001.6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

136195861..136273855 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529832.3 → XP_006529895.1 calmodulin-regulated spectrin-associated protein 2 isoform X1

UniProtKB/TrEMBL

B2RRE3

Conserved Domains (4) summary

PHA03247
Location:917 → 1028

PHA03247; large tegument protein UL36; Provisional

pfam11971
Location:237 → 315

CAMSAP_CH; CAMSAP CH domain

pfam08683
Location:1342 → 1460

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam17095
Location:731 → 789

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_006529834.4 → XP_006529897.1 calmodulin-regulated spectrin-associated protein 2 isoform X2

UniProtKB/TrEMBL

B2RRE3

Conserved Domains (4) summary

PHA03247
Location:906 → 1017

PHA03247; large tegument protein UL36; Provisional

pfam11971
Location:226 → 304

CAMSAP_CH; CAMSAP CH domain

pfam08683
Location:1331 → 1449

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam17095
Location:720 → 778

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_011248066.4 → XP_011246368.1 calmodulin-regulated spectrin-associated protein 2 isoform X4

Conserved Domains (3) summary

PHA03247
Location:515 → 626

PHA03247; large tegument protein UL36; Provisional

pfam08683
Location:940 → 1058

CAMSAP_CKK; Microtubule-binding calmodulin-regulated spectrin-associated

pfam17095
Location:329 → 387

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin
XM_036153216.1 → XP_036009109.1 calmodulin-regulated spectrin-associated protein 2 isoform X3

UniProtKB/TrEMBL

B2RRE3

Conserved Domains (3) summary

PHA03247
Location:917 → 1028

PHA03247; large tegument protein UL36; Provisional

pfam11971
Location:237 → 315

CAMSAP_CH; CAMSAP CH domain

pfam17095
Location:731 → 789

CAMSAP_CC1; Spectrin-binding region of Ca2+-Calmodulin

RNA

XR_004934125.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001081360.1: Suppressed sequence

Description

NM_001081360.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.