Dusp23 dual specificity phosphatase 23 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dusp23provided by MGI
Official Full Name: dual specificity phosphatase 23provided by MGI
Primary source: MGI:MGI:1915690
See related: Ensembl:ENSMUSG00000026544 AllianceGenome:MGI:1915690
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LDP-3; 1300005N15Rik
Summary: Predicted to enable protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in cilium assembly and dephosphorylation. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human DUSP23 (dual specificity phosphatase 23). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in mammary gland adult (RPKM 20.1), kidney adult (RPKM 17.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H3; 1 80.05 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (172458336..172460504, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (172630769..172632974, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that DUSP23 controls the association between alpha- and beta-catenin by promoting dephosphorylation of Tyr142 and identify a previously unrecognized role for DUSP23 in regulating E-cadherin adherens junctions.
Title: A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine/serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity protein phosphatase 23

Names: low molecular mass dual specificity phosphatase 3; low-molecular-mass dual-specificity phosphatase

NP_081001.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026725.3 → NP_081001.1 dual specificity protein phosphatase 23

Status: VALIDATED

Source sequence(s)

AC131177

Consensus CDS

CCDS15518.1

UniProtKB/Swiss-Prot

Q6NT99, Q9CW48

Related

ENSMUSP00000027826.6, ENSMUST00000027826.7

Conserved Domains (1) summary

COG2453
Location:63 → 150

CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]