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    ALR2 putative Mg(2+) transporter ALR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850494, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ALR2
    Official Full Name
    putative Mg(2+) transporter ALR2
    Primary source
    SGD:S000001844
    Locus tag
    YFL050C
    See related
    AllianceGenome:SGD:S000001844; FungiDB:YFL050C; VEuPathDB:YFL050C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables inorganic cation transmembrane transporter activity. Involved in magnesium ion transport and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ALR2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (33272..35848, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene DNA-binding domain containing protein Neighboring gene uncharacterized protein Neighboring gene Swp82p Neighboring gene Emp47p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large Mg(2+)-dependent currents are associated with the increased expression of ALR1 in Saccharomyces cerevisiae. Liu GJ, et al. FEMS Microbiol Lett, 2002 Aug 6. PMID 12167543
    2. The function of Alr1p of Saccharomyces cerevisiae in cadmium detoxification: insights from phylogenetic studies and particle-induced X-ray emission. Kern AL, et al. Biometals, 2005 Feb. PMID 15865408
    3. Oligomerization of the Mg2+-transport proteins Alr1p and Alr2p in yeast plasma membrane. Wachek M, et al. FEBS J, 2006 Sep. PMID 16903865
    4. Manipulation of intracellular magnesium levels in Saccharomyces cerevisiae with deletion of magnesium transporters. da Costa BM, et al. Appl Microbiol Biotechnol, 2007 Nov. PMID 17926032
    5. Overexpression of the Saccharomyces cerevisiae magnesium transport system confers resistance to aluminum ion. MacDiarmid CW, et al. J Biol Chem, 1998 Jan 16. PMID 9430719

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables inorganic cation transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables magnesium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular magnesium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in magnesium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in magnesium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    putative Mg(2+) transporter ALR2
    NP_116604.1
    • Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      33272..35848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179917.1 → NP_116604.1  TPA: putative Mg(2+) transporter ALR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116604.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTI0, P43553
      UniProtKB/TrEMBL
      G2WD91, N1P4G7
      Conserved Domains (1) summary
      cd12829
      Location:455 → 796
      Alr1p-like; Saccharomyces cerevisiae Alr1p-like subfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43553.1

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