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    DIG2 Dig2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852091, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DIG2
    Official Full Name
    Dig2p
    Primary source
    SGD:S000002888
    Locus tag
    YDR480W
    See related
    AllianceGenome:SGD:S000002888; FungiDB:YDR480W; VEuPathDB:YDR480W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RST2
    Summary
    Enables transcription corepressor activity. Involved in cellular response to pheromone; negative regulation of growth of unicellular organism as a thread of attached cells; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of Ste12p-Dig1p-Dig2p complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DIG2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1417399..1418370)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Snm1p Neighboring gene Pex29p Neighboring gene alkaline phosphatase PHO8 Neighboring gene U2-type spliceosomal complex subunit CWC21

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of extragenic suppressors of the yeast sec12 ts mutation. Nakano A. J Biochem, 1996 Sep. PMID 8902631
    2. Transcriptional activation upon pheromone stimulation mediated by a small domain of Saccharomyces cerevisiae Ste12p. Pi H, et al. Mol Cell Biol, 1997 Nov. PMID 9343403, Free PMC Article
    3. Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Bardwell L, et al. Proc Natl Acad Sci U S A, 1998 Dec 22. PMID 9860980, Free PMC Article
    4. Two regulators of Ste12p inhibit pheromone-responsive transcription by separate mechanisms. Olson KA, et al. Mol Cell Biol, 2000 Jun. PMID 10825185, Free PMC Article
    5. Regulation of mating and filamentation genes by two distinct Ste12 complexes in Saccharomyces cerevisiae. Chou S, et al. Mol Cell Biol, 2006 Jul. PMID 16782869, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the transcriptional repressors Dig1 and Dig2 positively affect transcription by stabilizing Ste12
      Title: Positive roles for negative regulators in the mating response of yeast.
    2. Dig1 and Dig2 contribute to the retention of phosphorylated Fus3 in the nucleus.
      Title: The pheromone-induced nuclear accumulation of the Fus3 MAPK in yeast depends on its phosphorylation state and on Dig1 and Dig2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to pheromone IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of invasive growth in response to glucose limitation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Ste12p-Dig1p-Dig2p complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dig2p
    NP_010768.1
    • MAP kinase-responsive inhibitor of the Ste12p transcription factor; involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p; DIG2 has a paralog, DIG1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1417399..1418370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180788.1 → NP_010768.1  TPA: Dig2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010768.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTA3, Q03373
      UniProtKB/TrEMBL
      A6ZZ69, B3LFI6, C7GKR9, C8Z638, N1P7D6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03373.1

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