HST4 NAD-dependent histone deacetylase HST4 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HST4
Official Full Name: NAD-dependent histone deacetylase HST4
Primary source: SGD:S000002599
Locus tag: YDR191W
See related: AllianceGenome:SGD:S000002599; FungiDB:YDR191W; VEuPathDB:YDR191W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables NAD-dependent histone deacetylase activity. Involved in several processes, including mRNA transcription; replication-born double-strand break repair via sister chromatid exchange; and subtelomeric heterochromatin formation. Located in mitochondrion and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HST4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (842337..843449)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance.
Title: The Amazing Acrobat: Yeast's Histone H3K56 Juggles Several Important Roles While Maintaining Perfect Balance.
A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.
Title: A novel role for Dun1 in the regulation of origin firing upon hyper-acetylation of H3K56.
This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so
Title: Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation.
Hst4p plays a pivotal role in biotin metabolism and cellular energy homeostasis, and data supports that Hst4p is a functional yeast homologue of the sirtuin deacetylase SIRT3.
Title: Biotin starvation causes mitochondrial protein hyperacetylation and partial rescue by the SIRT3-like deacetylase Hst4p.
Our results suggest that Hst3 and Hst4 regulate replicative lifespan through their ability to deacetylate histone H3-K56 to minimize genomic instability.
Title: Hst3 and Hst4 histone deacetylases regulate replicative lifespan by preventing genome instability in Saccharomyces cerevisiae.
HST3 HST4 play critical roles in maintaining the hypoacetylated state of lysine56 on histone H3 within silent chromatin.
Title: HST3/HST4-dependent deacetylation of lysine 56 of histone H3 in silent chromatin.
cells lacking Hst4p, in which H3 K56 is constitutively hyperacetylated, exhibit hallmarks of spontaneous DNA damage
Title: Histone H3 K56 hyperacetylation perturbs replisomes and causes DNA damage.
That acetylation of Histone H3 by Hst4 takes place during checkpoint regulation was determined.
Title: Cell cycle and checkpoint regulation of histone H3 K56 acetylation by Hst3 and Hst4.
Specific functions were found for HST4.
Title: Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables histone H3K14 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K18 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K4 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K56 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H3K9 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone H4K16 deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables histone deacetylase activity, NAD-dependent	IBA Inferred from Biological aspect of Ancestor more info
enables histone deacetylase activity, NAD-dependent	IDA Inferred from Direct Assay more info	PubMed
enables histone deacetylase activity, NAD-dependent	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in heterochromatin formation	IEA Inferred from Electronic Annotation more info
involved_in mRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in pericentric heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in rDNA heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication-born double-strand break repair via sister chromatid exchange	IBA Inferred from Biological aspect of Ancestor more info
involved_in replication-born double-strand break repair via sister chromatid exchange	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in short-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in subtelomeric heterochromatin formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in mating-type region heterochromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NAD-dependent histone deacetylase HST4

NP_010477.3

EC 2.3.1.286

NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

842337..843449

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180499.3 → NP_010477.3 TPA: NAD-dependent histone deacetylase HST4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010477.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VSH4, P53688

UniProtKB/TrEMBL

B3LG92, B5VG85, C7GN06, C8Z5A6, N1P6I5

Conserved Domains (1) summary

COG0846
Location:77 → 370

SIR2; NAD-dependent protein deacetylase, SIR2 family [Posttranslational modification, protein turnover, chaperones]