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    SAC6 fimbrin [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAC6
    Official Full Name
    fimbrin
    Primary source
    SGD:S000002536
    Locus tag
    YDR129C
    See related
    AllianceGenome:SGD:S000002536; FungiDB:YDR129C; VEuPathDB:YDR129C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ABP67
    Summary
    Enables actin filament binding activity and protein-macromolecule adaptor activity. Involved in formin-nucleated actin cable assembly. Located in actin cortical patch and actin filament bundle. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 76; congenital diaphragmatic hernia; and nicotine dependence. Orthologous to human LCP1 (lymphocyte cytosolic protein 1); PLS1 (plastin 1); and PLS3 (plastin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAC6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (713340..715379, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene pentafunctional protein ARO1p Neighboring gene Mtc5p Neighboring gene Fin1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isoform-specific complementation of the yeast sac6 null mutation by human fimbrin. Adams AE, et al. Mol Cell Biol, 1995 Jan. PMID 7799970, Free PMC Article
    2. Requirement of yeast fimbrin for actin organization and morphogenesis in vivo. Adams AE, et al. Nature, 1991 Dec 5. PMID 1956405
    3. A role for cross-linking proteins in actin filament network organization and force generation. Hill JM, et al. Proc Natl Acad Sci U S A, 2024 Oct 22. PMID 39405356,
    4. Interaction in vivo and in vitro between the yeast fimbrin, SAC6P, and a polymerization-defective yeast actin (V266G and L267G). Cheng D, et al. J Biol Chem, 1999 Dec 10. PMID 10585472
    5. Suppressor analysis of fimbrin (Sac6p) overexpression in yeast. Sandrock TM, et al. Genetics, 1999 Apr. PMID 10101157, Free PMC Article

    See all (148) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAC6 protein mutant was found to be defective in apical actin patch localization.
      Title: Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin filament network formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formin-nucleated actin cable assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in formin-nucleated actin cable assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cortical patch IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in actin filament bundle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament bundle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cellular bud tip HDA PubMed 
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection tip HDA PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    fimbrin
    NP_010414.3
    • Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      713340..715379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180437.3 → NP_010414.3  TPA: fimbrin [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010414.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSB5, P32599
      UniProtKB/TrEMBL
      A6ZY91, C7GIN7, C8Z545, N1P6M4
      Conserved Domains (1) summary
      COG5069
      Location:1 → 640
      SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32599.1

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