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    HTL1 Htl1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850384, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HTL1
    Official Full Name
    Htl1p
    Primary source
    SGD:S000006439
    Locus tag
    YCR020W-B
    See related
    AllianceGenome:SGD:S000006439; FungiDB:YCR020W-B; VEuPathDB:YCR020W-B
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to contribute to chromatin binding activity. Involved in nucleosome disassembly and transcription elongation by RNA polymerase II. Part of RSC-type complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HTL1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (155320..155556)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Pet18p Neighboring gene Mak31p Neighboring gene Hsp30p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The HTL1 gene (YCR020W-b) of Saccharomyces cerevisiae is necessary for growth at 37 degrees C, and for the conservation of chromosome stability and fertility. Lanzuolo C, et al. Yeast, 2001 Oct. PMID 11571756
    2. A study of biochemical and functional interactions of Htl1p, a putative component of the Saccharomyces cerevisiae, Rsc chromatin-remodeling complex. Florio C, et al. Gene, 2007 Jun 15. PMID 17400406
    3. Dissecting the pet18 mutation in Saccharomyces cerevisiae: HTL1 encodes a 7-kDa polypeptide that interacts with components of the RSC complex. Lu YM, et al. Mol Genet Genomics, 2003 Jun. PMID 12684875
    4. The defects in cell wall integrity and G2-M transition of the ∆htl1 mutant are interconnected. Wang SL, et al. Yeast, 2012 Jan. PMID 22113782
    5. HTL1 encodes a novel factor that interacts with the RSC chromatin remodeling complex in Saccharomyces cerevisiae. Romeo MJ, et al. Mol Cell Biol, 2002 Dec. PMID 12417720, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The defects in cell wall integrity and the G(2)-M transition of the htl1 mutant are interconnected.
      Title: The defects in cell wall integrity and G2-M transition of the ∆htl1 mutant are interconnected.
    2. Htl1p binding to the RSC complex is direct and physiologically relevant
      Title: A study of biochemical and functional interactions of Htl1p, a putative component of the Saccharomyces cerevisiae, Rsc chromatin-remodeling complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to chromatin binding IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleosome disassembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RSC-type complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Htl1p
    NP_009949.1
    • Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      155320..155556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184313.1 → NP_009949.1  TPA: Htl1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009949.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR30, Q9URQ5
      UniProtKB/TrEMBL
      A6ZTK2, B3LU92, C7GW75, C8Z4B0, G2WA38, N1P9A3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9URQ5.1

    Gene LinkOut

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