U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    FUB1 Fub1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850439, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    FUB1
    Official Full Name
    Fub1p
    Primary source
    SGD:S000000672
    Locus tag
    YCR076C
    See related
    AllianceGenome:SGD:S000000672; FungiDB:YCR076C; VEuPathDB:YCR076C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables proteasome binding activity. Predicted to be involved in chromatin organization. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See FUB1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (249293..250045, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene cystinosin-like protein ERS1 Neighboring gene Ego2p Neighboring gene Pat1p Neighboring gene type 2C protein phosphatase PTC6

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Yeast PI31 inhibits the proteasome by a direct multisite mechanism. Rawson S, et al. Nat Struct Mol Biol, 2022 Aug. PMID 35927584, Free PMC Article
    2. Barrier proteins remodel and modify chromatin to restrict silenced domains. Oki M, et al. Mol Cell Biol, 2004 Mar. PMID 14966276, Free PMC Article
    3. N-terminal α7 deletion of the proteasome 20S core particle substitutes for yeast PI31 function. Yashiroda H, et al. Mol Cell Biol, 2015 Jan. PMID 25332237, Free PMC Article
    4. Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex. Hatanaka A, et al. Genes Genet Syst, 2011. PMID 22362029
    5. The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation. Buck TM, et al. Mol Cell Proteomics, 2020 Nov. PMID 32868373, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables proteasome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Fub1p
    NP_010001.1
    • Proteasome-binding protein; interacts physically with multiple subunits of the 20S proteasome and genetically with genes encoding 20S core particle and 19S regulatory particle subunits; specifically blocks all three proteasome active sites; exhibits boundary activity which inhibits the propagation of heterochromatic silencing; contains a PI31 proteasome regulator domain and sequence similarity with human PSMF1, a proteasome inhibitor; not an essential gene

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      249293..250045 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178785.1 → NP_010001.1  TPA: Fub1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010001.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR79, P25659
      UniProtKB/TrEMBL
      G2WA86
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25659.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools