U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    AME1 Ame1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852512, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    AME1
    Official Full Name
    Ame1p
    Primary source
    SGD:S000000415
    Locus tag
    YBR211C
    See related
    AllianceGenome:SGD:S000000415; FungiDB:YBR211C; VEuPathDB:YBR211C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ARP100
    Summary
    Involved in attachment of spindle microtubules to kinetochore and protein localization to kinetochore. Located in kinetochore. Part of COMA complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See AME1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (646158..647132, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene tRNA-Glu Neighboring gene Erv15p Neighboring gene Ngr1p Neighboring gene bifunctional precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase MET8

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A multipurpose transposon system for analyzing protein production, localization, and function in Saccharomyces cerevisiae. Ross-Macdonald P, et al. Proc Natl Acad Sci U S A, 1997 Jan 7. PMID 8990184, Free PMC Article
    2. Spindle checkpoint maintenance requires Ame1 and Okp1. Pot I, et al. Cell Cycle, 2005 Oct. PMID 16177574
    3. The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments. Knockleby J, et al. Cell Cycle, 2009 Aug 15. PMID 19597337
    4. Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae. Boeckmann L, et al. Mol Biol Cell, 2013 Jun. PMID 23637466, Free PMC Article
    5. Bub1 kinase and Sgo1 modulate pericentric chromatin in response to altered microtubule dynamics. Haase J, et al. Curr Biol, 2012 Mar 20. PMID 22365852, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
      Title: Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
    2. Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
      Title: Cdc4 phospho-degrons allow differential regulation of Ame1(CENP-U) protein stability across the cell cycle.
    3. Findings reveal a new role for the central kinetochore in promoting Sli15 function, and suggest functional Ame1 is required for the correction of defective attachments by promoting the localization of Sli15/INCENP at kinetochores.
      Title: The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments.
    4. Ame1 and Okp1 are required for a sustained checkpoint arrest in the presence of mis-segregated chromosomes
      Title: Spindle checkpoint maintenance requires Ame1 and Okp1.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in attachment of spindle microtubules to kinetochore IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COMA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole body HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ame1p
    NP_009770.3
    • Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      646158..647132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178559.3 → NP_009770.3  TPA: Ame1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009770.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQK7, P38313
      UniProtKB/TrEMBL
      G2W9L4, N1P8P2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38313.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools