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    PSY4 Psy4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852234, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PSY4
    Official Full Name
    Psy4p
    Primary source
    SGD:S000000142
    Locus tag
    YBL046W
    See related
    AllianceGenome:SGD:S000000142; FungiDB:YBL046W; VEuPathDB:YBL046W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HSM6
    Summary
    Enables protein phosphatase regulator activity. Involved in negative regulation of DNA damage checkpoint. Located in cytoplasm and nucleus. Part of protein phosphatase 4 complex. Orthologous to human PPP4R2 (protein phosphatase 4 regulatory subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PSY4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (132424..133749)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Rrt1p Neighboring gene Ede1p Neighboring gene ubiquinol--cytochrome-c reductase subunit COR1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. [HSM6 gene is identical to PSY4 gene in Saccharomyces cerevisiae yeasts]. Fedorov DV, et al. Genetika, 2013 Mar. PMID 23755532
    2. The Saccharomyces cerevisiae orthologue of the human protein phosphatase 4 core regulatory subunit R2 confers resistance to the anticancer drug cisplatin. Hastie CJ, et al. FEBS J, 2006 Jul. PMID 16857015
    3. [Spontaneous mutation rate changes in saccharomyces cerevisiae at combinations of hsm3 and hsm6 mutations with rad52 mutation]. Chernenkov AIu, et al. Genetika, 2014 Feb. PMID 25711034
    4. A synthetic biology approach reveals diverse and dynamic CDK response profiles via multisite phosphorylation of NLS-NES modules. Faustova I, et al. Sci Adv, 2022 Aug 19. PMID 35977012, Free PMC Article
    5. Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage. Vázquez-Martin C, et al. FEBS J, 2008 Aug. PMID 18647348

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. epistatic. Our data show that the PSY4 gene plays a key role in the regulation of cell withdrawal from checkpoint induced by DNA disturbances.
      Title: [HSM6 gene is identical to PSY4 gene in Saccharomyces cerevisiae yeasts].
    2. Results suggest that the trimeric Pph3p-Psy4p-Psy2p complex may dephosphorylate both gammaH2AX and Rad53p.
      Title: Characterization of the role of a trimeric protein phosphatase complex in recovery from cisplatin-induced versus noncrosslinking DNA damage.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein phosphatase 4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein phosphatase 4 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein phosphatase 4 complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Psy4p
    NP_009507.1
    • Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      132424..133749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178286.1 → NP_009507.1  TPA: Psy4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009507.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPV2, P38193, Q6B302
      UniProtKB/TrEMBL
      B3LNI4, G2W8W1
      Conserved Domains (1) summary
      pfam09184
      Location:5 → 246
      PPP4R2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38193.1

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