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    RFM1 Rfm1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RFM1
    Official Full Name
    Rfm1p
    Primary source
    SGD:S000005805
    Locus tag
    YOR279C
    See related
    AllianceGenome:SGD:S000005805; FungiDB:YOR279C; VEuPathDB:YOR279C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein-macromolecule adaptor activity. Involved in mitotic cell cycle; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA-templated DNA replication initiation. Part of histone deacetylase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RFM1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (843698..844630, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uroporphyrinogen-III synthase HEM4 Neighboring gene putative serine hydrolase Neighboring gene Plp2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction trap experiment with CDC6. Zavec PB, et al. Pflugers Arch, 2000 Jan. PMID 28176084
    2. The duplicated deacetylases Sir2 and Hst1 subfunctionalized by acquiring complementary inactivating mutations. Froyd CA, et al. Mol Cell Biol, 2011 Aug. PMID 21690292, Free PMC Article
    3. The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Dhingra N, et al. Proc Natl Acad Sci U S A, 2021 Feb 23. PMID 33602817, Free PMC Article
    4. Rfm1, a novel tethering factor required to recruit the Hst1 histone deacetylase for repression of middle sporulation genes. McCord R, et al. Mol Cell Biol, 2003 Mar. PMID 12612074, Free PMC Article
    5. Control of replication initiation and heterochromatin formation in Saccharomyces cerevisiae by a regulator of meiotic gene expression. Irlbacher H, et al. Genes Dev, 2005 Aug 1. PMID 16077008, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated DNA replication initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rfm1p
    NP_014922.3
    • Component of the Sum1p-Rfm1p-Hst1p complex; Rfm1p tethers the Hst1p histone deacetylase to the DNA-binding protein Sum1p; complex is involved in transcriptional repression of middle sporulation genes and in initiation of DNA replication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      843698..844630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183698.3 → NP_014922.3  TPA: Rfm1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014922.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2X8, Q12192
      UniProtKB/TrEMBL
      B5VSF9, C8ZH29, N1NWW9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12192.1

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