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    MPD1 protein disulfide isomerase MPD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854462, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MPD1
    Official Full Name
    protein disulfide isomerase MPD1
    Primary source
    SGD:S000005814
    Locus tag
    YOR288C
    See related
    AllianceGenome:SGD:S000005814; FungiDB:YOR288C; VEuPathDB:YOR288C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein disulfide isomerase activity and protein-disulfide reductase (glutathione) activity. Involved in protein folding. Located in endoplasmic reticulum and fungal-type vacuole. Orthologous to human PDIA6 (protein disulfide isomerase family A member 6). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MPD1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (852121..853077, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase RDL2 Neighboring gene rRNA-processing protein RRP36 Neighboring gene uncharacterized protein Neighboring gene tRNA-Ala

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of a yeast gene, MPD1, the overexpression of which suppresses inviability caused by protein disulfide isomerase depletion. Tachikawa H, et al. FEBS Lett, 1995 Aug 7. PMID 7649260
    2. Yeast Mpd1p reveals the structural diversity of the protein disulfide isomerase family. Vitu E, et al. J Mol Biol, 2008 Dec 19. PMID 18845159
    3. Functional differences between human and yeast protein disulfide isomerase family proteins. Kimura T, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219835
    4. Functional differences in yeast protein disulfide isomerases. Nørgaard P, et al. J Cell Biol, 2001 Feb 5. PMID 11157982, Free PMC Article
    5. The contributions of protein disulfide isomerase and its homologues to oxidative protein folding in the yeast endoplasmic reticulum. Xiao R, et al. J Biol Chem, 2004 Nov 26. PMID 15377672

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that Mpd1 binding to Sec61 is a prerequisite for CPY* ERAD and confirm a role of Sec61 in ERAD of misfolded secretory proteins.
      Title: Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation.
    2. structural analysis of Mpd1p reveals the structural diversity of the protein disulfide isomerase family
      Title: Yeast Mpd1p reveals the structural diversity of the protein disulfide isomerase family.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein disulfide isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein-disulfide reductase (glutathione) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-disulfide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-disulfide reductase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein-disulfide reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    protein disulfide isomerase MPD1
    NP_014931.3
    • Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      852121..853077 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183707.3 → NP_014931.3  TPA: protein disulfide isomerase MPD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014931.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Y6, Q12404
      UniProtKB/TrEMBL
      A6ZPC3, B3LJV2, C7GWA4, C8ZH38, G2WNF4, N1NXD6
      Conserved Domains (2) summary
      cd03002
      Location:30 → 150
      PDI_a_MPD1_like; PDI family, MPD1-like subfamily; composed of eukaryotic proteins similar to Saccharomyces cerevisiae MPD1 protein, which contains a single redox active TRX domain located at the N-terminus, and an ER retention signal at the C-terminus indicative of an ...
      TIGR01130
      Location:30 → 275
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12404.1

    Gene LinkOut

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