SNF2 SWI/SNF catalytic subunit SNF2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNF2
Official Full Name: SWI/SNF catalytic subunit SNF2
Primary source: SGD:S000005816
Locus tag: YOR290C
See related: AllianceGenome:SGD:S000005816; FungiDB:YOR290C; VEuPathDB:YOR290C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GAM1; HAF1; SWI2; TYE3
Summary: Enables several functions, including ATP-dependent chromatin remodeler activity; DNA binding activity; and lysine-acetylated histone binding activity. Involved in several processes, including DNA metabolic process; aggrephagy; and positive regulation of cell adhesion involved in single-species biofilm formation. Located in nucleus. Part of SWI/SNF complex. Used to study cancer. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 4; Nicolaides-Baraitser syndrome; blepharophimosis-impaired intellectual development syndrome; and cancer (multiple). Orthologous to human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2) and SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SNF2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (855147..860258, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structure of the yeast Swi/Snf complex in a nucleosome free state.
Title: Structure of the yeast Swi/Snf complex in a nucleosome free state.
Snf2 shows altered interactions with the DNA in different nucleotide states, providing the structural basis for DNA translocation; findings suggest a fundamental mechanism for the DNA translocation that underlies chromatin remodelling
Title: Mechanism of DNA translocation underlying chromatin remodelling by Snf2.
RecA-like domain 2 of DNA-dependent ATPase A domain, a SWI2 protein, mediates conformational integrity and ATP hydrolysis.
Title: RecA-like domain 2 of DNA-dependent ATPase A domain, a SWI2/SNF2 protein, mediates conformational integrity and ATP hydrolysis.
The path of DNA strands through the ATPase domains indicates the presence of contacts conserved with single strand translocases and additional contacts with both strands that are unique to Snf2 related proteins.
Title: Structure of the chromatin remodelling enzyme Chd1 bound to a ubiquitinylated nucleosome.
The findings uncover a link between Snf2 expression and the splicing of PTC7 and establish a previously unknown role for the SWI/SNF complex in the transition of yeast cells from fermentative to respiratory modes of metabolism.
Title: Chromatin-remodeling SWI/SNF complex regulates coenzyme Q(6) synthesis and a metabolic shift to respiration in yeast.
The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break.
Title: The SWI/SNF ATP-dependent nucleosome remodeler promotes resection initiation at a DNA double-strand break in yeast.
the cryo-electron microscopy structure of chromatin remodeller Switch/sucrose non-fermentable (SWI2/SNF2) from Saccharomyces cerevisiae bound to the nucleosome
Title: Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure.
Gcn5, Snf2, and Ydj1 cooperate in eviction of promoter nucleosomes genome-wide, achieving robust transcription of the most highly expressed subset of genes in yeast.
Title: Genome-wide cooperation by HAT Gcn5, remodeler SWI/SNF, and chaperone Ydj1 in promoter nucleosome eviction and transcriptional activation.
The interaction between Swi2p and Sir3p is key for SWI/SNF to promote resistance to replication stress in vivo and for establishment of heterochromatin at telomeres.
Title: Direct interactions promote eviction of the Sir3 heterochromatin protein by the SWI/SNF chromatin remodeling enzyme.
Both remodelers, Ino80p and Snf2p are required to recruit RNA polymerase II and targeted histone acetylation, indicating that remodelers are recruited to the CUP1 promoter before RNA polymerase II and histone acetylases.
Title: Co-dependent recruitment of Ino80p and Snf2p is required for yeast CUP1 activation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent chromatin remodeler activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleosomal DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleosome array spacer activity	IBA Inferred from Biological aspect of Ancestor more info
enables rDNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA strand invasion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in aggrephagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell adhesion involved in single-species biofilm formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mating type switching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SWI/SNF catalytic subunit SNF2

NP_014933.3

Catalytic subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

855147..860258 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183709.3 → NP_014933.3 TPA: SWI/SNF catalytic subunit SNF2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014933.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2Y8, P22082

UniProtKB/TrEMBL

G2WNF6, N1NVY5

Conserved Domains (5) summary

cd05519
Location:1550 → 1652

Bromo_SNF2; Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of ...

PLN03142
Location:650 → 1297

PLN03142; Probable chromatin-remodeling complex ATPase chain; Provisional

pfam07529
Location:617 → 660

HSA

pfam08880
Location:248 → 281

QLQ

pfam14619
Location:1299 → 1369

SnAC; Snf2-ATP coupling, chromatin remodelling complex