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    LEU9 2-isopropylmalate synthase LEU9 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LEU9
    Official Full Name
    2-isopropylmalate synthase LEU9
    Primary source
    SGD:S000005634
    Locus tag
    YOR108W
    See related
    AllianceGenome:SGD:S000005634; FungiDB:YOR108W; VEuPathDB:YOR108W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 2-isopropylmalate synthase activity. Involved in L-leucine biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LEU9 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (523027..524841)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene SNAP receptor VAM3 Neighboring gene GTPase-activating protein RGS2 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 Neighboring gene transcription factor TFIIIC subunit TFC7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification by functional analysis of the gene encoding alpha-isopropylmalate synthase II (LEU9) in Saccharomyces cerevisiae. Casalone E, et al. Yeast, 2000 Apr. PMID 10790691
    2. Diversification of Paralogous α-Isopropylmalate Synthases by Modulation of Feedback Control and Hetero-Oligomerization in Saccharomyces cerevisiae. López G, et al. Eukaryot Cell, 2015 Jun. PMID 25841022, Free PMC Article
    3. Metabolomic approach for improving ethanol stress tolerance in Saccharomyces cerevisiae. Ohta E, et al. J Biosci Bioeng, 2016 Apr. PMID 26344121
    4. The yeast mitochondrial carrier Leu5p and its human homologue Graves' disease protein are required for accumulation of coenzyme A in the matrix. Prohl C, et al. Mol Cell Biol, 2001 Feb. PMID 11158296, Free PMC Article
    5. Roles of dom34:hbs1 in nonstop protein clearance from translocators for normal organelle protein influx. Izawa T, et al. Cell Rep, 2012 Sep 27. PMID 22981232

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2-isopropylmalate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 2-isopropylmalate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 2-isopropylmalate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-isopropylmalate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables 2-isopropylmalate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-leucine biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in L-leucine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    2-isopropylmalate synthase LEU9
    NP_014751.1
    • Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      523027..524841
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183527.1 → NP_014751.1  TPA: 2-isopropylmalate synthase LEU9 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2G7, Q12166
      UniProtKB/TrEMBL
      B3LJF1, N1NWK7
      Conserved Domains (1) summary
      TIGR00970
      Location:34 → 596
      leuA_yeast; 2-isopropylmalate synthase, yeast type
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12166.1

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