RPB11 DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: RPB11
Official Full Name: DNA-directed RNA polymerase II core subunit RPB11
Primary source: SGD:S000005365
Locus tag: YOL005C
See related: AllianceGenome:SGD:S000005365; FungiDB:YOL005C; VEuPathDB:YOL005C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to RNA polymerase II activity and RNA-dependent RNA polymerase activity. Involved in termination of RNA polymerase II transcription. Part of RNA polymerase II, core complex. Orthologous to human POLR2J (RNA polymerase II subunit J); POLR2J2 (RNA polymerase II subunit J2); and POLR2J3 (RNA polymerase II subunit J3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See RPB11 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (315813..316175, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

An in vitro assay with the tombusvirus replicase indicated that Rpb11p affects TBSV replication and recombination only indirectly, via regulating p33 and p92(pol) levels.
Title: Host transcription factor Rpb11p affects tombusvirus replication and recombination via regulating the accumulation of viral replication proteins.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
contributes_to RNA polymerase II activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II activity	IEA Inferred from Electronic Annotation more info
contributes_to RNA-dependent RNA polymerase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in RNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase II transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-directed RNA polymerase complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II, core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II, core complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA polymerase II, core complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA-directed RNA polymerase II core subunit RPB11

NP_014638.1

RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

315813..316175 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183259.1 → NP_014638.1 TPA: DNA-directed RNA polymerase II core subunit RPB11 [Saccharomyces cerevisiae S288C]

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W262, P38902

UniProtKB/TrEMBL

A6ZNK1, B3LJ51, C7GJV7, C8ZHW0, G2WMM6, N1P2V7

Conserved Domains (1) summary

cd06926
Location:13 → 105

RNAP_II_RPB11; RPB11 subunit of Eukaryotic RNA polymerase II