SAM50 SAM complex subunit SAM50 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SAM50
Official Full Name: SAM complex subunit SAM50
Primary source: SGD:S000004971
Locus tag: YNL026W
See related: AllianceGenome:SGD:S000004971; FungiDB:YNL026W; VEuPathDB:YNL026W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: OMP85; TOB55
Summary: Enables protein transmembrane transporter activity. Involved in protein insertion into mitochondrial outer membrane and protein-containing complex assembly. Located in mitochondrial outer membrane. Part of SAM complex. Human ortholog(s) of this gene implicated in metabolic dysfunction-associated steatotic liver disease. Orthologous to human SAMM50 (SAMM50 sorting and assembly machinery component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SAM50 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (581920..583374)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the polypeptide transport-associated domain of Sam50 is not essential for recognition of beta-barrel precursors but instead promotes the release of precursor proteins from the SAM complex
Title: Biogenesis of mitochondrial β-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex.
Assembly of newly synthesized Tob55 into preexisting TOB complexes depended on Tob38 but did not require Mas37
Title: Assembly of the TOB complex of mitochondria.
These results demonstrate that the N-terminal domain of Tob55 recognizes precursors of beta-barrel proteins.
Title: The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in protein insertion into mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein insertion into mitochondrial outer membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SAM complex	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	HDA more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in outer membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SAM complex subunit SAM50

NP_014372.1

Component of the Sorting and Assembly Machinery (SAM) complex; the SAM (or TOB) complex is located in the mitochondrial outer membrane; the complex binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

581920..583374

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182865.1 → NP_014372.1 TPA: SAM complex subunit SAM50 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014372.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1F2, P53969

UniProtKB/TrEMBL

A6ZS53, B5VR11, C7GWP4, E9P977, G2WM78, N1NWQ0

Conserved Domains (1) summary

COG4775
Location:1 → 483

BamA; Outer membrane protein assembly factor BamA [Cell wall/membrane/envelope biogenesis]