Strap serine/threonine kinase receptor associated protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Strapprovided by MGI
Official Full Name: serine/threonine kinase receptor associated proteinprovided by MGI
Primary source: MGI:MGI:1329037
See related: Ensembl:ENSMUSG00000030224 AllianceGenome:MGI:1329037
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Unrip
Summary: Enables U2 snRNP binding activity; mRNA binding activity; and signaling receptor binding activity. Involved in alternative mRNA splicing, via spliceosome; neuron differentiation; and protein-RNA complex assembly. Acts upstream of or within negative regulation of transcription by RNA polymerase II and negative regulation of transforming growth factor beta receptor signaling pathway. Is active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; metanephros; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in adenocarcinoma; colorectal carcinoma; large cell carcinoma; lung carcinoma; and squamous cell neoplasm. Orthologous to human STRAP (serine/threonine kinase receptor associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 42.9), testis adult (RPKM 34.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 67.27 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (137712080..137728928)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (137735082..137751930)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism.
Title: Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism.
STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.
Title: STRAP regulates alternative splicing fidelity during lineage commitment of mouse embryonic stem cells.
Loss of Strap selectively induced Cyp26A1 expression in mouse EBs, suggesting a potential role of STRAP in RA signaling.
Title: Serine Threonine Kinase Receptor-Associated Protein Deficiency Impairs Mouse Embryonic Stem Cells Lineage Commitment Through CYP26A1-Mediated Retinoic Acid Homeostasis.
LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
Title: LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
Strap associates with Csde1 and affects expression of select Csde1-bound transcripts
Title: Strap associates with Csde1 and affects expression of select Csde1-bound transcripts.
STRAP is a new scaffold protein that functions in Toll-like receptor-mediated immune responses. STRAP specifically binds TGF beta-activated kinase 1 and IKKalpha along with NF-kappaB subunit p65, leading to enhanced association between TAK1, IKKalpha, and p65, and subsequent facilitation of p65 phosphorylation and nuclear translocation. The C-terminal region of STRAP is essential for its functional activity in upregula...
Title: STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway.
these results suggest that STRAP increases invasion and metastasis of colorectal cancer partly through inhibiting ubiquitin-dependent degradation of beta-catenin and promoting Wnt/beta-catenin signaling
Title: Novel role of STRAP in progression and metastasis of colorectal cancer through Wnt/β-catenin signaling.
findings indicate serine/threonine kinase receptor associated protein (STRAP) is expressed in the mouse ovary and is capable of regulating development of small follicles in a stage-dependent manner
Title: Serine threonine kinase receptor associated protein regulates early follicle development in the mouse ovary.
this study shows that STRAP is a positive regulator of the TLR3-meditated NF-kappaB and IRF signaling pathway
Title: STRAP positively regulates TLR3-triggered signaling pathway.
STRAP Ser(188) phosphorylation in the liver is tightly associated with cell death and proliferation through ASK1, TGF-beta, p53, and PI3K/PDK1 pathways, resulting in apoptotic cell death.
Title: A crucial role for the phosphorylation of STRAP at Ser(188) by MPK38 in STRAP-dependent cell death through ASK1, TGF-β, p53, and PI3K/PDK1 signaling pathways.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4) 1 citation
Gene trapped (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW557906 (e-PCR)
- UniSTS:179483

RH126628 (e-PCR)
- UniSTS:208044

RH126305 (e-PCR)
- UniSTS:163013

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables U2 snRNP binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in alternative mRNA splicing, via spliceosome	ISO Inferred from Sequence Orthology more info	PubMed
involved_in anatomical structure development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of gastrointestinal epithelium	IEA Inferred from Electronic Annotation more info
involved_in maintenance of gastrointestinal epithelium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_positive_effect negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-RNA complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spliceosomal snRNP assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in spliceosomal snRNP assembly	ISO Inferred from Sequence Orthology more info
involved_in spliceosomal snRNP assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of SMN complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SMN complex	ISO Inferred from Sequence Orthology more info
part_of SMN complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SMN-Sm protein complex	ISO Inferred from Sequence Orthology more info
part_of SMN-Sm protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine-threonine kinase receptor-associated protein

Names: UNR-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011499.3 → NP_035629.2 serine-threonine kinase receptor-associated protein

See identical proteins and their annotated locations for NP_035629.2

Status: VALIDATED

Source sequence(s)

AK145971, AK147179

Consensus CDS

CCDS51945.1

UniProtKB/Swiss-Prot

Q8BP89, Q8C6F6, Q9Z1Z2

UniProtKB/TrEMBL

B2RUC7

Related

ENSMUSP00000068267.7, ENSMUST00000064910.7

Conserved Domains (3) summary

COG2319
Location:11 → 292

WD40; WD40 repeat [General function prediction only]

cd00200
Location:9 → 293

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:104 → 141

7WD40; WD40 repeat [structural motif]