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    Sec61b SEC61 translocon subunit beta [ Mus musculus (house mouse) ]

    Gene ID: 66212, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sec61bprovided by MGI
    Official Full Name
    SEC61 translocon subunit betaprovided by MGI
    Primary source
    MGI:MGI:1913462
    See related
    Ensembl:ENSMUSG00000053317 AllianceGenome:MGI:1913462
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1190006C12Rik
    Summary
    Enables ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation; post-translational protein targeting to membrane, translocation; and retrograde protein transport, ER to cytosol. Located in endoplasmic reticulum quality control compartment. Orthologous to human SEC61B (SEC61 translocon subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 203.0), colon adult (RPKM 171.1) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec61b in Genome Data Viewer
    Location:
    4 B1; 4 26.03 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (47474661..47483233)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (47474661..47483233)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10143 Neighboring gene microfibrillar-associated protein 1B pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3491 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:47487387-47487624 Neighboring gene ALG2 alpha-1,3/1,6-mannosyltransferase Neighboring gene predicted gene, 42283 Neighboring gene STARR-seq mESC enhancer starr_10145 Neighboring gene STARR-seq mESC enhancer starr_10146 Neighboring gene predicted gene, 42284 Neighboring gene predicted gene, 32487

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PERK-dependent compartmentalization of ERAD and unfolded protein response machineries during ER stress. Kondratyev M, et al. Exp Cell Res, 2007 Oct 1. PMID 17707796
    2. A critical role of VMP1 in lipoprotein secretion. Morishita H, et al. Elife, 2019 Sep 17. PMID 31526472, Free PMC Article
    3. A novel quality control compartment derived from the endoplasmic reticulum. Kamhi-Nesher S, et al. Mol Biol Cell, 2001 Jun. PMID 11408579, Free PMC Article
    4. Sequential actin-based pushing forces drive meiosis I chromosome migration and symmetry breaking in oocytes. Yi K, et al. J Cell Biol, 2013 Mar 4. PMID 23439682, Free PMC Article
    5. Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum (ER) translocation sites, leads to ER stress. Hori O, et al. Mol Cell Biol, 2006 Jun. PMID 16705175, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102034

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables epidermal growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables epidermal growth factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in post-translational protein targeting to membrane, translocation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde protein transport, ER to cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Sec61 translocon complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sec61 translocon complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum quality control compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum quality control compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein transport protein Sec61 subunit beta
    Names
    Sec61 beta subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024171.2 → NP_077133.1  protein transport protein Sec61 subunit beta

      Status: PROVISIONAL

      Source sequence(s)
      AK004505
      Consensus CDS
      CCDS38759.1
      UniProtKB/Swiss-Prot
      Q9CQS8
      Related
      ENSMUSP00000067681.6, ENSMUST00000065678.6
      Conserved Domains (1) summary
      pfam03911
      Location:54 → 91
      Sec61_beta; Sec61beta family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      47474661..47483233
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQS8.3 GenPept UniProtKB/Swiss-Prot:Q9CQS8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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