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    Cd274 CD274 antigen [ Mus musculus (house mouse) ]

    Gene ID: 60533, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cd274provided by MGI
    Official Full Name
    CD274 antigenprovided by MGI
    Primary source
    MGI:MGI:1926446
    See related
    Ensembl:ENSMUSG00000016496 AllianceGenome:MGI:1926446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
    Summary
    The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]
    Expression
    Broad expression in thymus adult (RPKM 7.4), mammary gland adult (RPKM 5.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd274 in Genome Data Viewer
    Location:
    19 C1; 19 23.88 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29339428..29365495)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29362107..29388095)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52390 Neighboring gene relaxin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9996 Neighboring gene STARR-positive B cell enhancer ABC_E3250 Neighboring gene plasminogen receptor, C-terminal lysine transmembrane protein Neighboring gene STARR-positive B cell enhancer ABC_E5694 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29465786-29466087 Neighboring gene predicted gene, 36043 Neighboring gene STARR-seq mESC enhancer starr_45884 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29493177-29493330 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene STARR-positive B cell enhancer mm9_chr19:29505524-29505825 Neighboring gene STARR-seq mESC enhancer starr_45885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:29528717-29528916 Neighboring gene RIKEN cDNA A930007I19 gene Neighboring gene STARR-positive B cell enhancer ABC_E3251

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables receptor ligand activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in T cell costimulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in T cell costimulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell costimulation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in TRIF-dependent toll-like receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TRIF-dependent toll-like receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipopolysaccharide IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of CD8-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of CD8-positive, alpha-beta T cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell mediated immune response to tumor cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of T cell mediated immune response to tumor cell ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of T cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of activated T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of tumor necrosis factor superfamily cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of tumor necrosis factor superfamily cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-10 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to cytokine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to cytokine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in recycling endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    programmed cell death 1 ligand 1
    Names
    B7 homolog 1
    PDCD1 ligand 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021893.3NP_068693.1  programmed cell death 1 ligand 1 precursor

      See identical proteins and their annotated locations for NP_068693.1

      Status: REVIEWED

      Source sequence(s)
      AC119228, AF317088, AI645624, BY193530
      Consensus CDS
      CCDS29735.1
      UniProtKB/Swiss-Prot
      Q9EP73
      UniProtKB/TrEMBL
      Q3U472
      Related
      ENSMUSP00000016640.8, ENSMUST00000016640.8
      Conserved Domains (2) summary
      smart00409
      Location:151225
      IG; Immunoglobulin
      cl11960
      Location:40117
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      29339428..29365495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251020.2XP_030106880.1  programmed cell death 1 ligand 1 isoform X1

      UniProtKB/Swiss-Prot
      Q9EP73
      UniProtKB/TrEMBL
      Q3U472
      Conserved Domains (2) summary
      smart00409
      Location:151225
      IG; Immunoglobulin
      cl11960
      Location:40117
      Ig; Immunoglobulin domain
    2. XM_030251021.2XP_030106881.1  programmed cell death 1 ligand 1 isoform X2

      Conserved Domains (2) summary
      smart00409
      Location:114188
      IG; Immunoglobulin
      cl11960
      Location:380
      Ig; Immunoglobulin domain