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    Papss2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23972, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Papss2provided by MGI
    Official Full Name
    3'-phosphoadenosine 5'-phosphosulfate synthase 2provided by MGI
    Primary source
    MGI:MGI:1330223
    See related
    Ensembl:ENSMUSG00000024899 AllianceGenome:MGI:1330223
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    bm; Sk2; AtpsU2; Atpsk2; 1810018P12Rik
    Summary
    Enables adenylylsulfate kinase activity and sulfate adenylyltransferase (ATP) activity. Involved in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process. Acts upstream of or within blood coagulation; bone development; and sulfate assimilation. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; heart; limb; sensory organ; and skeleton. Used to study spondyloepimetaphyseal dysplasia, Pakistani type. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 50.1), small intestine adult (RPKM 40.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Papss2 in Genome Data Viewer
    Location:
    19 C1; 19 27.46 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (32573072..32644587)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (32595669..32667187)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene multiple inositol polyphosphate histidine phosphatase 1 Neighboring gene STARR-seq mESC enhancer starr_45949 Neighboring gene predicted gene, 36419 Neighboring gene STARR-seq mESC enhancer starr_45950 Neighboring gene predicted gene, 36492 Neighboring gene ATPase family, AAA domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32786522-32786822 Neighboring gene STARR-positive B cell enhancer mm9_chr19:32787156-32787457 Neighboring gene STARR-seq mESC enhancer starr_45951 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32828923-32829124 Neighboring gene STARR-positive B cell enhancer ABC_E7646 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:32830866-32830975 Neighboring gene killin, p53-regulated DNA replication inhibitor pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Defects in the cartilaginous growth plates of brachymorphic mice. Orkin RW, et al. J Cell Biol, 1977 May. PMID 67117, Free PMC Article
    2. Growth parameters in the epiphyseal cartilage of brachymorphic (bm/bm) mice. Vanky P, et al. Calcif Tissue Int, 2000 May. PMID 10773105
    3. Molecular cloning of a novel human PAPS synthetase which is differentially expressed in metastatic and non-metastatic colon carcinoma cells. Franzon VL, et al. Int J Biochem Cell Biol, 1999 May. PMID 10399321
    4. Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis. Ford-Hutchinson AF, et al. Osteoarthritis Cartilage, 2005 May. PMID 15882565
    5. Sulfate-activating enzymes in normal and brachymorphic mice: evidence for a channeling defect. Lyle S, et al. Biochemistry, 1995 Jan 24. PMID 7827052

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
      Title: Intestinal Sulfation Is Essential to Protect Against Colitis and Colonic Carcinogenesis.
    2. Genetic variants in SULT2A1, PAPSS2, and STS do not predispose to polycystic ovary syndrome.
      Title: Variants in SULT2A1 affect the DHEA sulphate to DHEA ratio in patients with polycystic ovary syndrome but not the hyperandrogenic phenotype.
    3. The results suggest that PAPSS2 might regulate osteoblast ALP activity and cell mineralization, probably through Smads signal pathways.
      Title: PAPSS2 promotes alkaline phosphates activity and mineralization of osteoblastic MC3T3-E1 cells by crosstalk and Smads signal pathways.
    4. hypertrophic chondrocytes show a dramatic down-regulation of Papss2 mRNA expression, indicating an important role of the gene product for cartilage growth and development in the embryo
      Title: Expression profile of Papss2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2) during cartilage formation and skeletal development in the mouse embryo.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylylsulfate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylylsulfate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfate kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nucleotidyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate adenylyltransferase (ATP) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sulfate adenylyltransferase (ATP) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within bone development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hormone metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfate assimilation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within sulfate assimilation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2
    Names
    PAPS synthase 2
    brachymorphic
    sulfurylase kinase 2
    NP_001188399.1
    NP_001347332.1
    NP_035994.2
    XP_006527127.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201470.1 → NP_001188399.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC162887, AK137675, BY224664
      Consensus CDS
      CCDS89376.1
      UniProtKB/TrEMBL
      A0A494B923, Q9QYS0
      Related
      ENSMUSP00000157455.2, ENSMUST00000235594.2
      Conserved Domains (3) summary
      cd00517
      Location:243 → 606
      ATPS; ATP-sulfurylase
      cd02027
      Location:43 → 193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:234 → 605
      sopT; ATP sulphurylase

    2. NM_001360403.1 → NP_001347332.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC162887
      Consensus CDS
      CCDS89377.1
      UniProtKB/TrEMBL
      A0A494BB18, Q9QYS0
      Related
      ENSMUSP00000158330.2, ENSMUST00000236290.2
      Conserved Domains (2) summary
      cd00517
      Location:245 → 608
      ATPS; ATP-sulfurylase
      cd02027
      Location:45 → 195
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...

    3. NM_011864.3 → NP_035994.2  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform 1

      See identical proteins and their annotated locations for NP_035994.2

      Status: VALIDATED

      Source sequence(s)
      AC162887
      Consensus CDS
      CCDS37960.1
      UniProtKB/Swiss-Prot
      O88428, Q5BKP4, Q9Z274
      UniProtKB/TrEMBL
      Q9QYS0
      Related
      ENSMUSP00000025833.7, ENSMUST00000025833.7
      Conserved Domains (3) summary
      cd00517
      Location:245 → 613
      ATPS; ATP-sulfurylase
      cd02027
      Location:45 → 195
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
      TIGR00339
      Location:236 → 612
      sopT; ATP sulphurylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      32573072..32644587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527064.5 → XP_006527127.1  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1

      UniProtKB/TrEMBL
      Q9QYS0
      Conserved Domains (2) summary
      cd00517
      Location:243 → 611
      ATPS; ATP-sulfurylase
      cd02027
      Location:43 → 193
      APSK; Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form important for the assimilation of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88428.2 GenPept UniProtKB/Swiss-Prot:O88428

    Gene LinkOut

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