Myo10 myosin X [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Myo10provided by MGI
Official Full Name: myosin Xprovided by MGI
Primary source: MGI:MGI:107716
See related: Ensembl:ENSMUSG00000022272 AllianceGenome:MGI:107716
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: myosin-X; mKIAA0799; D15Ertd600e
Summary: Predicted to enable cytoskeletal protein binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and plus-end directed microfilament motor activity. Acts upstream of or within positive regulation of cell-cell adhesion. Located in filopodium; neuron projection; and neuronal cell body. Is expressed in several structures, including autopod; central nervous system; genitourinary system; gut; and integumental system placode. Orthologous to human MYO10 (myosin X). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 20.6), ovary adult (RPKM 15.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 B1; 15 9.36 cM

Exon count:: 45

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (25622636..25813759)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (25622550..25813673)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesisdagger.
Title: MYO10 promotes transzonal projection-dependent germ line-somatic contact during mammalian folliculogenesis†.
Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Title: Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex.
Myosin-X is dispensable for spindle morphogenesis and positioning in the mouse oocyte.
Title: Myosin-X is dispensable for spindle morphogenesis and positioning in the mouse oocyte.
Circ-calm4 Serves as an miR-337-3p Sponge to Regulate Myo10 (Myosin 10) and Promote Pulmonary Artery Smooth Muscle Proliferation.
Title: Circ-calm4 Serves as an miR-337-3p Sponge to Regulate Myo10 (Myosin 10) and Promote Pulmonary Artery Smooth Muscle Proliferation.
Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.
Title: Myosin X Interaction with KIF13B, a Crucial Pathway for Netrin-1-Induced Axonal Development.
Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
Title: Lack of Myosin X Enhances Osteoclastogenesis and Increases Cell Surface Unc5b in Osteoclast-Lineage Cells.
Our current study reveals involvement of Myo10 in murine skin pigmentation.
Title: Myosin 10 is involved in murine pigmentation.
involvement of Myo10 not only in melanoblast migration, but also in melanoma development and metastasis.
Title: Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis.
Osteoclast differentiation is regulated by Myo10.
Title: Regulation of Osteoclast Differentiation by Myosin X.
These results suggest that the lever-arm of full-length myosin-X is flexible enough to processively steps on different actin filaments within the actin bundles of filopodia. This characteristic of myosin-X may facilitate actin filament convergence for filopodia production.
Title: Activated full-length myosin-X moves processively on filopodia with large steps toward diverse two-dimensional directions.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Spontaneous (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D15Mit127 (e-PCR), detects polymorphism
- UniSTS:127488

D15Ertd600e (e-PCR), detects polymorphism
- UniSTS:167172

AW048724 (e-PCR)
- UniSTS:180740

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables plus-end directed microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end directed microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell motility	IC Inferred by Curator more info	PubMed
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of filopodium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in filopodium	IBA Inferred from Biological aspect of Ancestor more info
located_in filopodium	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in filopodium tip	ISS Inferred from Sequence or Structural Similarity more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional myosin-X

Names: unconventional myosin-10; unconventionnal myosin-X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001353141.1 → NP_001340070.1 unconventional myosin-X isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC131178

UniProtKB/TrEMBL

Q80TR9

Conserved Domains (8) summary

smart00139
Location:911 → 1057

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1066 → 1320

B41; Band 4.1 homologues

cd13202
Location:1316 → 1404

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:577 → 678

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:743 → 868

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cl17171
Location:543 → 585

PH-like; Pleckstrin homology-like domain

cl22853
Location:2 → 85

Motor_domain; Myosin and Kinesin motor domain

cl27381
Location:3 → 334

Myosin_head; Myosin head (motor domain)
NM_001353142.1 → NP_001340071.1 unconventional myosin-X isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AK122371

Consensus CDS

CCDS88740.1

UniProtKB/TrEMBL

E9Q5G1, Q80TR9

Related

ENSMUSP00000022882.6, ENSMUST00000022882.12

Conserved Domains (10) summary

smart00139
Location:807 → 953

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:962 → 1216

B41; Band 4.1 homologues

cd13202
Location:1212 → 1300

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:473 → 574

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:639 → 764

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

TIGR02168
Location:94 → 235

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd17206
Location:955 → 1050

FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X

pfam16735
Location:136 → 186

MYO10_CC; Unconventional myosin-X coiled coil domain

NF033609
Location:243 → 426

MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

cl17171
Location:439 → 481

PH-like; Pleckstrin homology-like domain
NM_019472.2 → NP_062345.2 unconventional myosin-X isoform 1

See identical proteins and their annotated locations for NP_062345.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK028552, AK089482, AK122371

Consensus CDS

CCDS37049.1

UniProtKB/Swiss-Prot

F8VQB6, Q8R3S0, Q9JJY5

Related

ENSMUSP00000106087.2, ENSMUST00000110457.8

Conserved Domains (15) summary

smart00015
Location:741 → 763

IQ; Calmodulin-binding motif

smart00139
Location:1553 → 1699

MyTH4; Domain in Myosin and Kinesin Tails

smart00242
Location:58 → 739

MYSc; Myosin. Large ATPases

smart00295
Location:1708 → 1962

B41; Band 4.1 homologues

cd13202
Location:1958 → 2046

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:1219 → 1320

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:1385 → 1510

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cd14873
Location:77 → 727

MYSc_Myo10; class X myosin, motor domain

pfam00169
Location:1219 → 1314

PH; PH domain

pfam00373
Location:1803 → 1962

FERM_M; FERM central domain

pfam15346
Location:796 → 939

ARGLU; Arginine and glutamate-rich 1

pfam16735
Location:882 → 932

MYO10_CC; Unconventional myosin-X coiled coil domain

cl00155
Location:1705 → 1750

UBQ; Ubiquitin-like proteins

cl02488
Location:843 → 957

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl17171
Location:1185 → 1227

PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

25622636..25813759

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030248368.2 → XP_030104228.1 unconventional myosin-X isoform X1

UniProtKB/TrEMBL

Q80TR9

Conserved Domains (9) summary

smart00139
Location:910 → 1056

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1065 → 1319

B41; Band 4.1 homologues

COG5022
Location:2 → 333

COG5022; Myosin heavy chain [General function prediction only]

cd13202
Location:1315 → 1403

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:576 → 677

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:742 → 867

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cd17206
Location:1058 → 1153

FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X

cl22853
Location:1 → 84

Motor_domain; Myosin and Kinesin motor domain

cl17171
Location:542 → 584

PH-like; Pleckstrin homology-like domain
XM_030248369.1 → XP_030104229.1 unconventional myosin-X isoform X1

UniProtKB/TrEMBL

Q80TR9

Conserved Domains (9) summary

smart00139
Location:910 → 1056

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1065 → 1319

B41; Band 4.1 homologues

COG5022
Location:2 → 333

COG5022; Myosin heavy chain [General function prediction only]

cd13202
Location:1315 → 1403

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:576 → 677

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:742 → 867

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cd17206
Location:1058 → 1153

FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X

cl22853
Location:1 → 84

Motor_domain; Myosin and Kinesin motor domain

cl17171
Location:542 → 584

PH-like; Pleckstrin homology-like domain
XM_036159219.1 → XP_036015112.1 unconventional myosin-X isoform X3

UniProtKB/TrEMBL

E9Q5G1, Q80TR9

Conserved Domains (10) summary

smart00139
Location:807 → 953

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:962 → 1216

B41; Band 4.1 homologues

cd13202
Location:1212 → 1300

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:473 → 574

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:639 → 764

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

TIGR02168
Location:94 → 235

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd17206
Location:955 → 1050

FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X

pfam16735
Location:136 → 186

MYO10_CC; Unconventional myosin-X coiled coil domain

NF033609
Location:243 → 426

MSCRAMM_ClfA; MSCRAMM family adhesin clumping factor ClfA

cl17171
Location:439 → 481

PH-like; Pleckstrin homology-like domain
XM_006520025.5 → XP_006520088.1 unconventional myosin-X isoform X1

UniProtKB/TrEMBL

Q80TR9

Conserved Domains (9) summary

smart00139
Location:910 → 1056

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:1065 → 1319

B41; Band 4.1 homologues

COG5022
Location:2 → 333

COG5022; Myosin heavy chain [General function prediction only]

cd13202
Location:1315 → 1403

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:576 → 677

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:742 → 867

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

cd17206
Location:1058 → 1153

FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X

cl22853
Location:1 → 84

Motor_domain; Myosin and Kinesin motor domain

cl17171
Location:542 → 584

PH-like; Pleckstrin homology-like domain
XM_006520026.5 → XP_006520089.1 unconventional myosin-X isoform X2

UniProtKB/TrEMBL

Q80TR9

Conserved Domains (10) summary

smart00139
Location:831 → 977

MyTH4; Domain in Myosin and Kinesin Tails

smart00295
Location:986 → 1240

B41; Band 4.1 homologues

COG4372
Location:5 → 232

COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

cd13202
Location:1236 → 1324

FERM_C_MyoX; FERM domain C-lobe of Myosin X (MyoX, Myo10)

cd13296
Location:497 → 598

PH2_MyoX; Myosin X Pleckstrin homology (PH) domain, repeat 2

cd13297
Location:663 → 788

PH3_MyoX-like; Myosin X-like Pleckstrin homology (PH) domain, repeat 3

TIGR02680
Location:122 → 259

TIGR02680; TIGR02680 family protein

cd17206
Location:979 → 1074

FERM_F1_Myosin-X; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in unconventional myosin-X

pfam16735
Location:160 → 210

MYO10_CC; Unconventional myosin-X coiled coil domain

cl17171
Location:463 → 505

PH-like; Pleckstrin homology-like domain