U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Stra6 stimulated by retinoic acid gene 6 [ Mus musculus (house mouse) ]

    Gene ID: 20897, updated on 27-Nov-2024

    Summary

    Official Symbol
    Stra6provided by MGI
    Official Full Name
    stimulated by retinoic acid gene 6provided by MGI
    Primary source
    MGI:MGI:107742
    See related
    Ensembl:ENSMUSG00000032327 AllianceGenome:MGI:107742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable retinol transmembrane transporter activity. Acts upstream of or within establishment of localization in cell; positive regulation of receptor signaling pathway via JAK-STAT; and retinol transport. Located in plasma membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in syndromic microphthalmia 9. Orthologous to human STRA6 (signaling receptor and transporter of retinol STRA6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary adult (RPKM 12.1), subcutaneous fat pad adult (RPKM 11.6) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Stra6 in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57971076..58061287)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58063793..58154004)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene Cyp11a1 promoter region Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene Neighboring gene coiled-coil domain containing 33 Neighboring gene predicted gene 16130 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57960192-57960379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57981876-57982059 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene predicted gene, 39344

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinal binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables retinol transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinol transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adrenal gland development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in alveolar primary septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in blood vessel development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in camera-type eye development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in camera-type eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in developmental growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in diaphragm development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in digestive tract morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ductus arteriosus closure ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ear development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic camera-type eye formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in embryonic digestive tract development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in eyelid development in camera-type eye ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in face morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in feeding behavior ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in female genitalia development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in head development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in head morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in learning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lung vasculature development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuromuscular process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nose morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in paramesonephric duct development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of behavior ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pulmonary artery morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pulmonary valve morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within retinol transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within retinol transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinol transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in smooth muscle tissue development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in uterus morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular septum development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vitamin A import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vocal learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    receptor for retinol uptake STRA6
    Names
    retinoic acid-responsive protein
    retinol-binding protein receptor STRA6
    stimulated by retinoic acid gene 6 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001162475.1NP_001155947.1  receptor for retinol uptake STRA6

      See identical proteins and their annotated locations for NP_001155947.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC075657, CO043377
      Consensus CDS
      CCDS23236.1
      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Related
      ENSMUSP00000082820.3, ENSMUST00000085677.9
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    2. NM_001162476.1NP_001155948.1  receptor for retinol uptake STRA6

      See identical proteins and their annotated locations for NP_001155948.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC158996, BC075657, CF536552, CO043377
      Consensus CDS
      CCDS23236.1
      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Related
      ENSMUSP00000130232.2, ENSMUST00000170397.8
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    3. NM_001162479.1NP_001155951.1  receptor for retinol uptake STRA6

      See identical proteins and their annotated locations for NP_001155951.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      BC075657, CF742607, CO043377
      Consensus CDS
      CCDS23236.1
      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Related
      ENSMUSP00000128417.2, ENSMUST00000167479.8
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    4. NM_009291.2NP_033317.2  receptor for retinol uptake STRA6

      See identical proteins and their annotated locations for NP_033317.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
      Source sequence(s)
      AC158996, BC075657, CF730004, CF735552, CO043377, CX237908
      Consensus CDS
      CCDS23236.1
      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Related
      ENSMUSP00000034880.4, ENSMUST00000034880.10
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57971076..58061287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510941.3XP_006511004.2  receptor for retinol uptake STRA6 isoform X1

      See identical proteins and their annotated locations for XP_006511004.2

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    2. XM_036154773.1XP_036010666.1  receptor for retinol uptake STRA6 isoform X3

      Conserved Domains (1) summary
      pfam14752
      Location:41434
      RBP_receptor; Retinol binding protein receptor
    3. XM_017313262.1XP_017168751.1  receptor for retinol uptake STRA6 isoform X2

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      Conserved Domains (1) summary
      pfam14752
      Location:74690
      RBP_receptor; Retinol binding protein receptor
    4. XM_006510945.5XP_006511008.1  receptor for retinol uptake STRA6 isoform X1

      See identical proteins and their annotated locations for XP_006511008.1

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    5. XM_006510943.3XP_006511006.1  receptor for retinol uptake STRA6 isoform X1

      See identical proteins and their annotated locations for XP_006511006.1

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    6. XM_006510944.4XP_006511007.1  receptor for retinol uptake STRA6 isoform X1

      See identical proteins and their annotated locations for XP_006511007.1

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    7. XM_030244180.2XP_030100040.1  receptor for retinol uptake STRA6 isoform X1

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor
    8. XM_006510946.3XP_006511009.1  receptor for retinol uptake STRA6 isoform X1

      See identical proteins and their annotated locations for XP_006511009.1

      UniProtKB/Swiss-Prot
      O70491, Q6DIA8
      UniProtKB/TrEMBL
      A0A0R4J115
      Conserved Domains (1) summary
      pfam14752
      Location:41657
      RBP_receptor; Retinol binding protein receptor