U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Tpm1 tropomyosin 1, alpha [ Mus musculus (house mouse) ]

    Gene ID: 22003, updated on 3-Dec-2024

    Summary

    Official Symbol
    Tpm1provided by MGI
    Official Full Name
    tropomyosin 1, alphaprovided by MGI
    Primary source
    MGI:MGI:98809
    See related
    Ensembl:ENSMUSG00000032366 AllianceGenome:MGI:98809
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TM2; Tm3; Tmpa; Tpm-1; alpha-TM; TPM1kappa
    Summary
    Enables actin filament binding activity. Involved in cardiac muscle contraction; positive regulation of heart rate by epinephrine; and ventricular cardiac muscle tissue morphogenesis. Acts upstream of or within in utero embryonic development. Located in myofibril. Is expressed in several structures, including central nervous system; gut; heart; limb segment; and musculature. Used to study dilated cardiomyopathy 1Y and hypertrophic cardiomyopathy 3. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1Y; familial hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 3. Orthologous to human TPM1 (tropomyosin 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in bladder adult (RPKM 766.9), heart adult (RPKM 589.0) and 6 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tpm1 in Genome Data Viewer
    Location:
    9 C; 9 36.27 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66929872..66956954, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (67022590..67049672, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene lactamase, beta Neighboring gene STARR-seq mESC enhancer starr_24484 Neighboring gene predicted gene, 30639 Neighboring gene VISTA enhancer mm100 Neighboring gene STARR-positive B cell enhancer ABC_E6761 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66892840-66892949 Neighboring gene STARR-seq mESC enhancer starr_24488 Neighboring gene predicted gene 10646 Neighboring gene predicted gene, 22145 Neighboring gene predicted gene, 19299 Neighboring gene STARR-seq mESC enhancer starr_24489 Neighboring gene predicted gene, 40529

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin filament binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables disordered domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables structural constituent of cytoskeleton TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in muscle filament sliding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heart rate by epinephrine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ventricular cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in bleb ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of muscle thin filament tropomyosin TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tropomyosin alpha-1 chain
    Names
    alpha-tropomyosin
    tropomyosin 1 kappa
    tropomyosin-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164248.1NP_001157720.1  tropomyosin alpha-1 chain isoform Tpm1.1st

      See identical proteins and their annotated locations for NP_001157720.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.1, also known as variant 1) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.1st) is the same length, but has an alternate C-terminus, compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52845.1
      UniProtKB/Swiss-Prot
      P58771
      UniProtKB/TrEMBL
      Q545Y3
      Related
      ENSMUSP00000109315.4, ENSMUST00000113685.10
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    2. NM_001164249.1NP_001157721.1  tropomyosin alpha-1 chain isoform Tpm1.2st

      See identical proteins and their annotated locations for NP_001157721.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.2, also known as variant 2) lacks an in-frame exon and has an alternate in-frame exon compared to variant Tpm1.6. The encoded isoform (Tpm1.2st) is the same length but has a short region of sequence differences, compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52848.1
      UniProtKB/TrEMBL
      B7ZNL3
      Related
      ENSMUSP00000109335.2, ENSMUST00000113705.8
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    3. NM_001164250.1NP_001157722.1  tropomyosin alpha-1 chain isoform Tpm1.7cy

      See identical proteins and their annotated locations for NP_001157722.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.7, also known as variant 4) lacks an exon and contains another alternate exon compared to variant Tpm1.6. The encoded isoform (Tpm1.7cy) is the same length but has short regions of sequence differences and an alternate C-terminus, compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52846.1
      UniProtKB/TrEMBL
      E9Q450
      Related
      ENSMUSP00000109327.2, ENSMUST00000113697.8
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    4. NM_001164251.1NP_001157723.1  tropomyosin alpha-1 chain isoform Tpm1.5cy

      See identical proteins and their annotated locations for NP_001157723.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.5, also known as variant 5) differs in the 3' UTR and coding sequence, lacks internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.5cy) is the same length but has short regions of sequence differences, compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52847.1
      UniProtKB/TrEMBL
      Q8BP43
      Related
      ENSMUSP00000051888.10, ENSMUST00000050905.16
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    5. NM_001164252.1NP_001157724.1  tropomyosin alpha-1 chain isoform Tpm1.8cy

      See identical proteins and their annotated locations for NP_001157724.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.8, also known as variant 6) differs in the 5' UTR and coding sequence compared to variant Tpm1.6. The encoded isoform (Tpm1.8cy) has an alternate N-terminus compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52841.1
      UniProtKB/TrEMBL
      G5E8R1
      Related
      ENSMUSP00000109325.2, ENSMUST00000113695.8
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    6. NM_001164253.1NP_001157725.1  tropomyosin alpha-1 chain isoform Tpm1.9cy

      See identical proteins and their annotated locations for NP_001157725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.9, also known as variant 7) differs in the 5' UTR and coding sequence, lacks an alternate internal exon, and contains another alternate internal exon compared to variant Tpm1.6. The encoded isoform (Tpm1.9cy) has an alternate N-terminus, has a short internal region of sequence differences and is shorter, compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52843.1
      UniProtKB/TrEMBL
      G5E8R2
      Related
      ENSMUSP00000109326.2, ENSMUST00000113696.8
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    7. NM_001164254.1NP_001157726.1  tropomyosin alpha-1 chain isoform Tpm1.13

      See identical proteins and their annotated locations for NP_001157726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.13, also known as variant 8) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The encoded isoform (Tpm1.13) has alternate N- and C- termini and is shorter, compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    8. NM_001164255.1NP_001157727.1  tropomyosin alpha-1 chain isoform Tpm1.10br

      See identical proteins and their annotated locations for NP_001157727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.10, also known as variant 9) differs in the 3' UTR and coding sequence compared to variant Tpm1.6. The resulting isoform (9) has a shorter and distinct C-terminus compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52844.1
      UniProtKB/TrEMBL
      E9Q452
      Related
      ENSMUSP00000109323.2, ENSMUST00000113693.8
      Conserved Domains (1) summary
      pfam00261
      Location:48280
      Tropomyosin
    9. NM_001164256.1NP_001157728.1  tropomyosin alpha-1 chain isoform Tpm1.12br

      See identical proteins and their annotated locations for NP_001157728.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.12, also known as variant 10) differs in the 5' and 3' UTRs as well as the 5' and 3' coding sequences compared to variant Tpm1.6. The resulting isoform (Tpm1.12br) has shorter and distinct N- and C-termini compared to isoform Tpm1.6cy.
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS52842.1
      UniProtKB/TrEMBL
      G5E8R0
      Related
      ENSMUSP00000109320.2, ENSMUST00000113690.8
      Conserved Domains (1) summary
      pfam00261
      Location:12244
      Tropomyosin
    10. NM_024427.4NP_077745.2  tropomyosin alpha-1 chain isoform Tpm1.6cy

      See identical proteins and their annotated locations for NP_077745.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (Tpm1.6, also known as variant 3) represents one of the longest transcripts and encodes one of the longest isoforms (Tpm1.6cy).
      Source sequence(s)
      AC166370
      Consensus CDS
      CCDS23311.1
      UniProtKB/TrEMBL
      Q564G1
      Related
      ENSMUSP00000109337.3, ENSMUST00000113707.9
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      66929872..66956954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154840.1XP_036010733.1  tropomyosin alpha-1 chain isoform X7

      Conserved Domains (1) summary
      pfam00261
      Location:48280
      Tropomyosin
    2. XM_006511044.2XP_006511107.1  tropomyosin alpha-1 chain isoform X6

      See identical proteins and their annotated locations for XP_006511107.1

      UniProtKB/TrEMBL
      E9Q448
      Related
      ENSMUSP00000109331.2, ENSMUST00000113701.8
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    3. XM_030244241.1XP_030100101.1  tropomyosin alpha-1 chain isoform X13

      UniProtKB/TrEMBL
      F8WID5
      Related
      ENSMUSP00000034928.5, ENSMUST00000034928.12
      Conserved Domains (2) summary
      PRK12472
      Location:18127
      PRK12472; hypothetical protein; Provisional
      pfam00261
      Location:90324
      Tropomyosin
    4. XM_006511051.5XP_006511114.1  tropomyosin alpha-1 chain isoform X12

      See identical proteins and their annotated locations for XP_006511114.1

      UniProtKB/TrEMBL
      E9Q453
      Related
      ENSMUSP00000109319.2, ENSMUST00000113689.8
      Conserved Domains (1) summary
      pfam00261
      Location:12244
      Tropomyosin
    5. XM_006511040.4XP_006511103.1  tropomyosin alpha-1 chain isoform X1

      UniProtKB/TrEMBL
      E9Q454
      Related
      ENSMUSP00000109317.2, ENSMUST00000113687.8
      Conserved Domains (2) summary
      pfam00261
      Location:48259
      Tropomyosin
      pfam16526
      Location:1372
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    6. XM_011242715.3XP_011241017.1  tropomyosin alpha-1 chain isoform X3

      Conserved Domains (2) summary
      pfam00261
      Location:48259
      Tropomyosin
      pfam16526
      Location:1372
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    7. XM_006511039.4XP_006511102.1  tropomyosin alpha-1 chain isoform X2

      Conserved Domains (1) summary
      pfam00261
      Location:48259
      Tropomyosin
    8. XM_006511042.4XP_006511105.1  tropomyosin alpha-1 chain isoform X4

      See identical proteins and their annotated locations for XP_006511105.1

      UniProtKB/TrEMBL
      A0A2R2Y2P8
      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    9. XM_006511049.5XP_006511112.1  tropomyosin alpha-1 chain isoform X8

      UniProtKB/TrEMBL
      E9Q455
      Related
      ENSMUSP00000109316.2, ENSMUST00000113686.8
      Conserved Domains (1) summary
      pfam00261
      Location:12223
      Tropomyosin
    10. XM_011242716.4XP_011241018.1  tropomyosin alpha-1 chain isoform X9

      See identical proteins and their annotated locations for XP_011241018.1

      Conserved Domains (1) summary
      pfam00261
      Location:12223
      Tropomyosin
    11. XM_030244240.2XP_030100100.1  tropomyosin alpha-1 chain isoform X10

      UniProtKB/TrEMBL
      E9Q456
      Related
      ENSMUSP00000109314.2, ENSMUST00000113684.8
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin
    12. XM_006511041.2XP_006511104.1  tropomyosin alpha-1 chain isoform X5

      See identical proteins and their annotated locations for XP_006511104.1

      Conserved Domains (1) summary
      pfam00261
      Location:48282
      Tropomyosin
    13. XM_006511050.4XP_006511113.1  tropomyosin alpha-1 chain isoform X11

      See identical proteins and their annotated locations for XP_006511113.1

      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin