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    Rock1 Rho-associated coiled-coil containing protein kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 19877, updated on 4-Jan-2025

    Summary

    Official Symbol
    Rock1provided by MGI
    Official Full Name
    Rho-associated coiled-coil containing protein kinase 1provided by MGI
    Primary source
    MGI:MGI:107927
    See related
    Ensembl:ENSMUSG00000024290 AllianceGenome:MGI:107927
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rock-I; 1110055K06Rik
    Summary
    Predicted to enable Rho-dependent protein serine/threonine kinase activity and small GTPase binding activity. Involved in several processes, including podocyte cell migration; positive regulation of focal adhesion assembly; and response to angiotensin. Acts upstream of or within several processes, including apical constriction; bleb assembly; and negative regulation of motor neuron apoptotic process. Located in several cellular components, including cytoplasmic stress granule; lamellipodium; and ruffle. Is active in Schaffer collateral - CA1 synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and skeletal muscle. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.8), placenta adult (RPKM 6.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rock1 in Genome Data Viewer
    Location:
    18 A1; 18 4.91 cM
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (10064401..10182225, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (10064401..10182251, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43785 Neighboring gene developmental pluripotency associated 4 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43786 Neighboring gene THO complex 1 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene STARR-seq mESC enhancer starr_43787 Neighboring gene STARR-seq mESC enhancer starr_43788 Neighboring gene STARR-seq mESC enhancer starr_43789 Neighboring gene LSM6 homolog, U6 small nuclear RNA associated pseudogene Neighboring gene predicted gene, 26244 Neighboring gene STARR-seq mESC enhancer starr_43790 Neighboring gene high mobility group box 3 pseudogene Neighboring gene dyskeratosis congenita 1, dyskerin homolog pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (15)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables metal ion binding  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables small GTPase binding  
    enables small GTPase binding  
    Items 1 - 25 of 30
    Items 1 - 25 of 84
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction  
    acts_upstream_of_or_within Rho protein signal transduction PubMed 
    involved_in Rho protein signal transduction  
    acts_upstream_of_or_within actin cytoskeleton organization PubMed 
    involved_in actin cytoskeleton organization PubMed 
    involved_in actomyosin structure organization  
    acts_upstream_of_or_within apical constriction PubMed 
    acts_upstream_of_or_within bleb assembly PubMed 
    involved_in blood vessel diameter maintenance PubMed 
    involved_in canonical NF-kappaB signal transduction  
    involved_in chromatin remodeling  
    involved_in cortical actin cytoskeleton organization  
    involved_in cortical actin cytoskeleton organization  
    involved_in cytoskeleton organization  
    involved_in embryonic morphogenesis  
    involved_in epithelial to mesenchymal transition PubMed 
    involved_in leukocyte cell-cell adhesion  
    involved_in leukocyte migration  
    involved_in leukocyte tethering or rolling  
    involved_in leukocyte tethering or rolling  
    involved_in mRNA destabilization PubMed 
    involved_in membrane to membrane docking  
    involved_in membrane to membrane docking  
    involved_in mitotic cytokinesis  
    acts_upstream_of motor neuron apoptotic process PubMed 
    involved_in myoblast migration PubMed 
    involved_in negative regulation of amyloid precursor protein catabolic process  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of amyloid-beta formation  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of bicellular tight junction assembly  
    involved_in negative regulation of bicellular tight junction assembly  
    acts_upstream_of_or_within negative regulation of motor neuron apoptotic process PubMed 
    involved_in negative regulation of protein binding  
    involved_in neuron projection arborization  
    involved_in neuron projection arborization  
    involved_in neuron projection development  
    involved_in peptidyl-serine phosphorylation  
    involved_in podocyte cell migration PubMed 
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of amyloid-beta clearance  
    involved_in positive regulation of amyloid-beta clearance  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of autophagy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of cardiac muscle hypertrophy  
    involved_in positive regulation of connective tissue replacement  
    involved_in positive regulation of connective tissue replacement  
    involved_in positive regulation of dephosphorylation  
    involved_in positive regulation of dephosphorylation  
    involved_in positive regulation of focal adhesion assembly PubMed 
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of phosphatase activity  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of actin cytoskeleton organization  
    acts_upstream_of_or_within regulation of actin filament-based process PubMed 
    involved_in regulation of angiotensin-activated signaling pathway  
    involved_in regulation of angiotensin-activated signaling pathway  
    involved_in regulation of cell junction assembly  
    involved_in regulation of cell migration  
    involved_in regulation of cell migration  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of establishment of endothelial barrier  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of keratinocyte differentiation  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of microtubule cytoskeleton organization  
    involved_in regulation of neuron differentiation  
    involved_in regulation of neuron differentiation  
    involved_in regulation of synapse maturation PubMed 
    involved_in regulation of synapse maturation PubMed 
    involved_in regulation of synaptic vesicle endocytosis  
    involved_in regulation of synaptic vesicle endocytosis  
    involved_in response to angiotensin PubMed 
    involved_in response to transforming growth factor beta PubMed 
    involved_in response to transforming growth factor beta  
    Items 1 - 25 of 84
    Component Evidence Code Pubs
    located_in Golgi membrane  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in bleb  
    located_in centriole  
    is_active_in cytoplasm  
    is_active_in cytoplasmic stress granule  
    located_in cytoplasmic stress granule PubMed 
    is_active_in cytoskeleton  
    located_in cytoskeleton PubMed 
    located_in lamellipodium PubMed 
    located_in plasma membrane PubMed 
    located_in ruffle PubMed 

    General protein information

    Preferred Names
    rho-associated protein kinase 1
    Names
    Rho-associated coiled-coil forming kinase 1
    p160 ROCK-1
    p160ROCK
    rho-associated, coiled-coil-containing protein kinase 1
    rho-associated, coiled-coil-containing protein kinase I
    NP_033097.1
    XP_006525788.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009071.2NP_033097.1  rho-associated protein kinase 1

      Status: VALIDATED

      Source sequence(s)
      AA163962, AK077297, AK149793, DR754490, U58512
      Consensus CDS
      CCDS29053.2
      UniProtKB/Swiss-Prot
      P70335, Q8C3G4, Q8C7H0
      Related
      ENSMUSP00000069549.6, ENSMUST00000067947.7
      Conserved Domains (7) summary
      cd11639
      Location:489554
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      smart00220
      Location:76338
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1196
      Location:4221097
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:12291283
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11191225
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1
      pfam08912
      Location:9491014
      Rho_Binding; Rho Binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      10064401..10182225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525725.2XP_006525788.1  rho-associated protein kinase 1 isoform X1

      UniProtKB/Swiss-Prot
      P70335
      Conserved Domains (5) summary
      cd11639
      Location:488553
      HR1_ROCK1; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Rho-associated coiled-coil containing protein kinase 1
      COG1196
      Location:4191096
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00029
      Location:12281282
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01242
      Location:11181224
      PH_ROCK; Rho-associated coiled-coil containing protein kinase pleckstrin homology (PH) domain
      cd05622
      Location:2406
      STKc_ROCK1; Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1

    RNA

    1. XR_001782350.3 RNA Sequence

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