Psma7 proteasome subunit alpha 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Psma7provided by MGI
Official Full Name: proteasome subunit alpha 7provided by MGI
Primary source: MGI:MGI:1347070
See related: Ensembl:ENSMUSG00000027566 AllianceGenome:MGI:1347070
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C6-I
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in pancreas epithelium. Orthologous to human PSMA7 (proteasome 20S subunit alpha 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 74.2), CNS E14 (RPKM 56.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H4; 2 102.55 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (179678160..179684257, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (180036367..180042464, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of proteasomal subunit PSMA7 results in potent inhibition of retinoic acid induced gene-1 (RIG)-1 and MAVS-mediated interferon-beta promoter activity.
Title: Negative regulation of MAVS-mediated innate immune response by PSMA7.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IDA Inferred from Direct Assay more info	PubMed
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, alpha-subunit complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex, alpha-subunit complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit alpha type-7

Names: alpha-4; proteasome (prosome, macropain) subunit, alpha type 7; proteasome subunit RC6-1; proteasome subunit alpha-4

NP_001276405.1

EC 3.4.25.1

NP_036099.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001289476.1 → NP_001276405.1 proteasome subunit alpha type-7 isoform 2

See identical proteins and their annotated locations for NP_001276405.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK146765, AL663067, BU841938, BY779773, CJ307624, DV049235

UniProtKB/TrEMBL

Q3THL2

Related

ENSMUST00000126021.8

Conserved Domains (1) summary

cl00467
Location:1 → 141

Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
NM_011969.2 → NP_036099.1 proteasome subunit alpha type-7 isoform 1

See identical proteins and their annotated locations for NP_036099.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK146765, BU841938, BY779773, CJ307624, DV049235

Consensus CDS

CCDS17166.1

UniProtKB/Swiss-Prot

Q9Z2U0

UniProtKB/TrEMBL

Q3TN31, Q3UIT9, Q542H2

Related

ENSMUSP00000029082.9, ENSMUST00000029082.9

Conserved Domains (1) summary

cd03755
Location:3 → 211

proteasome_alpha_type_7; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...