Sorcs3 sortilin-related VPS10 domain containing receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sorcs3provided by MGI
Official Full Name: sortilin-related VPS10 domain containing receptor 3provided by MGI
Primary source: MGI:MGI:1913923
See related: Ensembl:ENSMUSG00000063434 AllianceGenome:MGI:1913923
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 6330404A12Rik
Summary: Involved in postsynaptic modulation of chemical synaptic transmission. Acts upstream of or within learning; memory; and regulation of long-term synaptic depression. Located in postsynaptic density. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including brain; cochlea; genitourinary system; retina; and trigeminal ganglion. Orthologous to human SORCS3 (sortilin related VPS10 domain containing receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cortex adult (RPKM 4.4), frontal lobe adult (RPKM 4.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D1; 19 41.32 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (48194464..48793944)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (48206025..48805505)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SorCS1 and SorLA expression were markedly reduced in the frontal cerebral cortex and to a minor extent in the hippocampus, whereas SorCS3 expression was solely reduced in the frontal cerebral cortex
Title: Amyloidosis causes downregulation of SorLA, SorCS1 and SorCS3 expression in mice.
our findings identified a novel role for VPS10P domain receptors SORCS1 and SORCS3 in hypothalamic control of metabolism through regulation of orexigenic peptide production.
Title: SORCS1 and SORCS3 control energy balance and orexigenic peptide production.
SorCS3 serves as a key regulator of synaptic transmission and plasticity. Results show that glutamate receptor functions are controlled by SorCS3 to secure correct functioning of excitatory synapses. The receptor plays a more central role in CA1 compared to the dentate gyrus, correlating well with the expression pattern. Reduced function of SorCS3 results in impaired synaptic mechanisms in the hippocampus.
Title: The sorting receptor SorCS3 is a stronger regulator of glutamate receptor functions compared to GABAergic mechanisms in the hippocampus.
Study demonstrates that SorCS3 expression is restricted to the developing and adult nervous system
Title: Spatiotemporal expression analysis of the growth factor receptor SorCS3.
Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
Title: Sortilin-related receptor SORCS3 is a postsynaptic modulator of synaptic depression and fear extinction.
SorCS3 and the homologous sorCS1 and sorCS2 genes were expressed in a combinatorial mostly non-overlapping pattern in the developing and mature central nervous system; activity-dependent induction of sorCS3 did not require protein synthesis
Title: The three sorCS genes are differentially expressed and regulated by synaptic activity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Markers

18.MMHAP85FLF3.seq (e-PCR)
- UniSTS:123403

AW045579 (e-PCR)
- UniSTS:166162

20.MMHAP32FLG2.seq (e-PCR)
- UniSTS:123468

D19Dcr59 (e-PCR), detects polymorphism
- UniSTS:532379

D19Dcr60 (e-PCR), detects polymorphism
- UniSTS:532380

D19Dcr61 (e-PCR), detects polymorphism
- UniSTS:532381

D19Dcr62 (e-PCR), detects polymorphism
- UniSTS:532382

D19Mit74 (e-PCR), detects polymorphism
- UniSTS:128414

D19Dcr63 (e-PCR), detects polymorphism
- UniSTS:532383

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of long-term synaptic depression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: VPS10 domain-containing receptor SorCS3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025696.3 → NP_079972.1 VPS10 domain-containing receptor SorCS3 precursor

Status: VALIDATED

Source sequence(s)

AC122363, AC126046, AC127434, AC141870

Consensus CDS

CCDS38020.1

UniProtKB/Swiss-Prot

Q8VI51, Q9CTR4

UniProtKB/TrEMBL

Q1HL22

Related

ENSMUSP00000077919.6, ENSMUST00000078880.6

Conserved Domains (3) summary

smart00602
Location:216 → 814

VPS10; VPS10 domain

pfam00801
Location:828 → 901

PKD; PKD domain

pfam15901
Location:658 → 814

Sortilin_C; Sortilin, neurotensin receptor 3, C-terminal