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    Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 [ Mus musculus (house mouse) ]

    Gene ID: 20512, updated on 9-Dec-2024

    Summary

    Official Symbol
    Slc1a3provided by MGI
    Official Full Name
    solute carrier family 1 (glial high affinity glutamate transporter), member 3provided by MGI
    Primary source
    MGI:MGI:99917
    See related
    Ensembl:ENSMUSG00000005360 AllianceGenome:MGI:99917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gmt1; Eaat1; GLAST; GLU-T; GluT-1; MGluT1; GLAST-1; B430115D02Rik
    Summary
    Enables glutamate binding activity and high-affinity L-glutamate transmembrane transporter activity. Involved in D-aspartate import across plasma membrane and cellular response to cocaine. Acts upstream of or within several processes, including L-glutamate import across plasma membrane; gamma-aminobutyric acid biosynthetic process; and nervous system development. Located in several cellular components, including cell surface; neuron projection; and neuronal cell body. Is expressed in several structures, including central nervous system; connective tissue; eye; foregut; and genitourinary system. Used to study low tension glaucoma. Human ortholog(s) of this gene implicated in episodic ataxia type 6. Orthologous to human SLC1A3 (solute carrier family 1 member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 107.1), cerebellum adult (RPKM 104.8) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Slc1a3 in Genome Data Viewer
    Location:
    15 A1; 15 3.82 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (8663608..8742648, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (8634124..8710807, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:8462039-8462148 Neighboring gene predicted gene, 49249 Neighboring gene STARR-seq mESC enhancer starr_37902 Neighboring gene STARR-seq mESC enhancer starr_37903 Neighboring gene STARR-seq mESC enhancer starr_37904 Neighboring gene STARR-seq mESC enhancer starr_37905 Neighboring gene STARR-seq mESC enhancer starr_37906 Neighboring gene predicted gene, 46508 Neighboring gene STARR-positive B cell enhancer ABC_E7359 Neighboring gene STARR-seq mESC enhancer starr_37907 Neighboring gene STARR-seq mESC enhancer starr_37908 Neighboring gene STARR-seq mESC enhancer starr_37909 Neighboring gene predicted gene, 57815 Neighboring gene STARR-seq mESC enhancer starr_37913 Neighboring gene STARR-seq mESC enhancer starr_37914 Neighboring gene predicted gene, 31340 Neighboring gene STARR-seq mESC enhancer starr_37917 Neighboring gene STARR-seq mESC enhancer starr_37918 Neighboring gene myotubularin related protein 3 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in D-aspartate import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in D-aspartate import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in D-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in D-aspartate import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in L-aspartate import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in L-aspartate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-aspartate import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within L-glutamate import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-glutamate import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within L-glutamate import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in L-glutamate import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-glutamate import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within L-glutamate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in L-glutamate transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within auditory behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chloride transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within cranial nerve development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gamma-aminobutyric acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular sodium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in malate-aspartate shuttle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within response to amino acid ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to light stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in basal plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
     
    part_of membrane protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    excitatory amino acid transporter 1
    Names
    glial high affinity glutamate transporter
    glutamate/aspartate transporter
    high-affinity neuronal glutamate transporter
    sodium-dependent glutamate/aspartate transporter 1
    solute carrier family 1, member 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_148938.3NP_683740.1  excitatory amino acid transporter 1

      See identical proteins and their annotated locations for NP_683740.1

      Status: VALIDATED

      Source sequence(s)
      AK031831, AK040798, BC058711, BY281420
      Consensus CDS
      CCDS27373.1
      UniProtKB/Swiss-Prot
      P56564, Q99P53
      UniProtKB/TrEMBL
      Q543U3, Q8C3T7, Q8C7W8
      Related
      ENSMUSP00000005493.8, ENSMUST00000005493.14
      Conserved Domains (1) summary
      pfam00375
      Location:50497
      SDF; Sodium:dicarboxylate symporter family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      8663608..8742648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159289.1XP_036015182.1  excitatory amino acid transporter 1 isoform X1

      UniProtKB/TrEMBL
      Q8C3T7, Q8C7W8
      Conserved Domains (1) summary
      pfam00375
      Location:5390
      SDF; Sodium:dicarboxylate symporter family