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    H2bc22 H2B clustered histone 22 [ Mus musculus (house mouse) ]

    Gene ID: 319188, updated on 9-Dec-2024

    Summary

    Official Symbol
    H2bc22provided by MGI
    Official Full Name
    H2B clustered histone 22provided by MGI
    Primary source
    MGI:MGI:2448409
    See related
    Ensembl:ENSMUSG00000069308 AllianceGenome:MGI:2448409
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hist1h2bp
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Aug 2015]
    Expression
    Broad expression in thymus adult (RPKM 257.9), colon adult (RPKM 133.4) and 23 other tissues See more
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    Genomic context

    See H2bc22 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.97 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21971652..21985731)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21787483..21801561)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1456 Neighboring gene H3 clustered histone 11 Neighboring gene STARR-seq mESC enhancer starr_33864 Neighboring gene H2A clustered histone 22 Neighboring gene STARR-positive B cell enhancer mm9_chr13:21894945-21895245 Neighboring gene H2B clustered histone 23 Neighboring gene H2A clustered histone 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    histone H2B type 1-P
    Names
    histone 1, H2bp
    histone cluster 1, H2bp

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290466.1NP_001277395.1  histone H2B type 1-P isoform 2

      See identical proteins and their annotated locations for NP_001277395.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal and tail, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AL589651
      Consensus CDS
      CCDS79168.1
      UniProtKB/Swiss-Prot
      Q64477, Q6P8V8, Q8CGP2
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00000100047.2, ENSMUST00000102982.2
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B
    2. NM_178202.2NP_835509.2  histone H2B type 1-P isoform 1

      See identical proteins and their annotated locations for NP_835509.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AV047260, BC061044
      Consensus CDS
      CCDS26298.2
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00000106099.3, ENSMUST00000110473.3
      Conserved Domains (2) summary
      pfam00125
      Location:3102
      Histone; Core histone H2A/H2B/H3/H4
      cl23830
      Location:12125
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21971652..21985731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516690.4XP_006516753.1  histone H2B type 1-P isoform X1

      See identical proteins and their annotated locations for XP_006516753.1

      UniProtKB/Swiss-Prot
      Q64477, Q6P8V8, Q8CGP2
      UniProtKB/TrEMBL
      A0JLV3
      Conserved Domains (1) summary
      smart00427
      Location:28124
      H2B; Histone H2B