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    Wdr70 WD repeat domain 70 [ Mus musculus (house mouse) ]

    Gene ID: 545085, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr70provided by MGI
    Official Full Name
    WD repeat domain 70provided by MGI
    Primary source
    MGI:MGI:1921020
    See related
    Ensembl:ENSMUSG00000039828 AllianceGenome:MGI:1921020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833422F06Rik
    Summary
    Predicted to enable enzyme binding activity. Predicted to be active in nucleus and site of double-strand break. Orthologous to human WDR70 (WD repeat domain 70). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.9), testis adult (RPKM 7.5) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Wdr70 in Genome Data Viewer
    Location:
    15 A1; 15 3.82 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (7902536..8138787, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (7873055..8099209, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37885 Neighboring gene glial cell line derived neurotrophic factor Neighboring gene STARR-seq mESC enhancer starr_37886 Neighboring gene basic transcription factor 3, pseudogene 16 Neighboring gene STARR-seq mESC enhancer starr_37887 Neighboring gene ribosomal protein L19, pseudogene 6 Neighboring gene STARR-positive B cell enhancer mm9_chr15:8047913-8048213 Neighboring gene STARR-seq mESC enhancer starr_37890 Neighboring gene STARR-seq mESC enhancer starr_37891 Neighboring gene STARR-seq mESC enhancer starr_37892 Neighboring gene nucleoporin 155 Neighboring gene STARR-seq mESC enhancer starr_37894 Neighboring gene ciliogenesis and planar polarity effector 1 Neighboring gene STARR-seq mESC enhancer starr_37895 Neighboring gene predicted gene, 46494 Neighboring gene predicted gene, 24144

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 70

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081402.1NP_001074871.1  WD repeat-containing protein 70 isoform 1

      See identical proteins and their annotated locations for NP_001074871.1

      Status: VALIDATED

      Source sequence(s)
      AC107747, AC123611, AC130656, AK159714
      Consensus CDS
      CCDS37033.1
      UniProtKB/Swiss-Prot
      Q3TWF6
      UniProtKB/TrEMBL
      G3X934
      Related
      ENSMUSP00000037340.7, ENSMUST00000045766.8
      Conserved Domains (2) summary
      sd00039
      Location:188230
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:180501
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001358788.1NP_001345717.1  WD repeat-containing protein 70 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107747, AK167464, BC051482, DV662602
      Consensus CDS
      CCDS88730.1
      UniProtKB/TrEMBL
      Q6P8I3
      Related
      ENSMUSP00000154067.2, ENSMUST00000227371.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      7902536..8138787 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159521.1XP_036015414.1  WD repeat-containing protein 70 isoform X1

      UniProtKB/Swiss-Prot
      Q3TWF6
      UniProtKB/TrEMBL
      G3X934
      Conserved Domains (2) summary
      sd00039
      Location:188230
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:180501
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017316701.2XP_017172190.1  WD repeat-containing protein 70 isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:2068
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:17285
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...