Poc1b POC1 centriolar protein B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Poc1bprovided by MGI
Official Full Name: POC1 centriolar protein Bprovided by MGI
Primary source: MGI:MGI:1918511
See related: Ensembl:ENSMUSG00000019952 AllianceGenome:MGI:1918511
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr51b; 4933430F16Rik
Summary: Acts upstream of or within several processes, including homeostasis of number of cells; single fertilization; and spermatid development. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole and ciliary basal body. Is expressed in ductus deferens; epididymis; ileum; metanephros; and testis. Used to study oligoasthenoteratozoospermia. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to human POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in testis adult (RPKM 19.9), CNS E11.5 (RPKM 7.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C3- D1; 10 51.06 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (98942918..99033936)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (99107082..99198074)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.
Title: Homozygous frameshift variant in POC1B causes male infertility with oligoasthenoteratozoospermia in human and mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AV011803 (e-PCR)
- UniSTS:165720

NoName (e-PCR)
- UniSTS:494956

D10Mit244 (e-PCR), detects polymorphism
- UniSTS:126148

BE136173 (e-PCR)
- UniSTS:208599

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular component organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
involved_in centriole replication	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within homeostasis of number of cells	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retina homeostasis	ISO Inferred from Sequence Orthology more info
involved_in retina homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within single fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within single fertilization	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within sperm flagellum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	ISO Inferred from Sequence Orthology more info
located_in ciliary basal body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: POC1 centriolar protein homolog B

Names: WD repeat domain 51B; WD repeat-containing protein 51B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027740.7 → NP_082016.1 POC1 centriolar protein homolog B

See identical proteins and their annotated locations for NP_082016.1

Status: VALIDATED

Source sequence(s)

AK050233, BC050888, BC144819, CO041491

Consensus CDS

CCDS36045.1

UniProtKB/Swiss-Prot

Q8BHD1

UniProtKB/TrEMBL

A6H699

Related

ENSMUSP00000020113.9, ENSMUST00000020113.15

Conserved Domains (3) summary

COG2319
Location:14 → 300

WD40; WD40 repeat [General function prediction only]

cd00200
Location:10 → 298

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:63 → 100

7WD40; WD40 repeat [structural motif]

RNA

NR_153333.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

BC050888, BC144819, CO041491

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

98942918..99033936

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155881.1 → XP_036011774.1 POC1 centriolar protein homolog B isoform X1

Conserved Domains (2) summary

sd00039
Location:15 → 51

7WD40; WD40 repeat [structural motif]

cl29593
Location:4 → 84

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...