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    Tktl2 transketolase-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 74419, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tktl2provided by MGI
    Official Full Name
    transketolase-like 2provided by MGI
    Primary source
    MGI:MGI:1921669
    See related
    Ensembl:ENSMUSG00000025519 AllianceGenome:MGI:1921669
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933401I19Rik
    Summary
    Predicted to enable thiamine pyrophosphate binding activity and transketolase activity. Predicted to be located in cytoplasm. Orthologous to human TKTL2 (transketolase like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 7.0) See more
    Orthologs
    human all
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    Genomic context

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    See Tktl2 in Genome Data Viewer
    Location:
    8 B3.1; 8 33.14 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (66964392..66971851)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66511740..66519199)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:69010363-69010546 Neighboring gene STARR-seq mESC enhancer starr_21673 Neighboring gene translation machinery associated 16 Neighboring gene predicted gene, 32568 Neighboring gene STARR-seq mESC enhancer starr_21675 Neighboring gene STARR-seq mESC enhancer starr_21676 Neighboring gene STARR-seq mESC enhancer starr_21677 Neighboring gene neuropeptide Y receptor Y5 Neighboring gene neuropeptide Y receptor Y1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CRISPR/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice†. Lu Y, et al. Biol Reprod, 2019 Aug 1. PMID 31201419, Free PMC Article
    2. Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Bulusu V, et al. Dev Cell, 2017 Feb 27. PMID 28245920, Free PMC Article
    3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transketolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transketolase-like protein 2
    NP_001258503.1
    NP_083203.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271574.1 → NP_001258503.1  transketolase-like protein 2

      See identical proteins and their annotated locations for NP_001258503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon structure in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC122800, AK029871, AV271587, BY090827
      Consensus CDS
      CCDS22334.1
      UniProtKB/Swiss-Prot
      A2RSH3, Q9D4D4
      UniProtKB/TrEMBL
      A0A0R4J2A3
      Related
      ENSMUSP00000138388.2, ENSMUST00000183187.2
      Conserved Domains (4) summary
      cd07033
      Location:324 → 479
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:17 → 623
      PRK05899; transketolase; Reviewed
      cd02012
      Location:22 → 270
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:495 → 617
      Transketolase_C; Transketolase, C-terminal domain

    2. NM_028927.3 → NP_083203.2  transketolase-like protein 2

      See identical proteins and their annotated locations for NP_083203.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK016603, BB019593, BY090827
      Consensus CDS
      CCDS22334.1
      UniProtKB/Swiss-Prot
      A2RSH3, Q9D4D4
      UniProtKB/TrEMBL
      A0A0R4J2A3
      Related
      ENSMUSP00000002025.4, ENSMUST00000002025.5
      Conserved Domains (4) summary
      cd07033
      Location:324 → 479
      TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins
      PRK05899
      Location:17 → 623
      PRK05899; transketolase; Reviewed
      cd02012
      Location:22 → 270
      TPP_TK; Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the ...
      pfam02780
      Location:495 → 617
      Transketolase_C; Transketolase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      66964392..66971851
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D4D4.1 GenPept UniProtKB/Swiss-Prot:Q9D4D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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