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    Elavl1 ELAV like RNA binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 15568, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Elavl1provided by MGI
    Official Full Name
    ELAV like RNA binding protein 1provided by MGI
    Primary source
    MGI:MGI:1100851
    See related
    Ensembl:ENSMUSG00000040028 AllianceGenome:MGI:1100851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HUR; Hua; 2410055N02Rik
    Summary
    Enables lncRNA binding activity and mRNA 3'-UTR AU-rich region binding activity. Involved in post-transcriptional regulation of gene expression; protein import into nucleus; and regulation of stem cell population maintenance. Acts upstream of or within positive regulation of translation. Located in several cellular components, including cytoplasmic stress granule; endoplasmic reticulum; and sarcoplasm. Part of ribonucleoprotein complex. Is active in cytoplasmic vesicle; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; central nervous system; connective tissue; early conceptus; and genitourinary system. Orthologous to human ELAVL1 (ELAV like RNA binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.0), whole brain E14.5 (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Elavl1 in Genome Data Viewer
    Location:
    8 A1.1; 8 2.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4334781..4375104, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4284781..4325140, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene cortexin 1 Neighboring gene translocase of inner mitochondrial membrane 44 Neighboring gene STARR-positive B cell enhancer ABC_E4988 Neighboring gene predicted gene, 50600 Neighboring gene C-C motif chemokine ligand 25 Neighboring gene predicted gene 7434

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The RNA-binding protein HuR is a negative regulator in adipogenesis. Siang DTC, et al. Nat Commun, 2020 Jan 10. PMID 31924774, Free PMC Article
    2. HuR Plays a Positive Role to Strengthen the Signaling Pathways of CD4(+) T Cell Activation and Th17 Cell Differentiation. Yu S, et al. J Immunol Res, 2021. PMID 34395636, Free PMC Article
    3. The RNA binding protein human antigen R is a gatekeeper of liver homeostasis. Subramanian P, et al. Hepatology, 2022 Apr. PMID 34519101
    4. RNA-binding protein HuR promotes growth of small intestinal mucosa by activating the Wnt signaling pathway. Liu L, et al. Mol Biol Cell, 2014 Nov 1. PMID 25165135, Free PMC Article
    5. ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis. Chang SH, et al. Proc Natl Acad Sci U S A, 2014 Dec 23. PMID 25422430, Free PMC Article

    See all (238) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HuR promotes triglyceride synthesis and intestinal fat absorption.
      Title: HuR promotes triglyceride synthesis and intestinal fat absorption.
    2. The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis.
      Title: The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis.
    3. Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.
      Title: Angiotension II directly bind P2X7 receptor to induce myocardial ferroptosis and remodeling by activating human antigen R.
    4. SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
      Title: SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer.
    5. HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
      Title: HuR promotes castration-resistant prostate cancer progression by altering ERK5 activation via posttranscriptional regulation of BCAT1.
    6. HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.
      Title: HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation.
    7. Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
      Title: Long noncoding RNA 1392 regulates MDA5 by interaction with ELAVL1 to inhibit coxsackievirus B5 infection.
    8. HuR modulation counteracts lipopolysaccharide response in murine macrophages.
      Title: HuR modulation counteracts lipopolysaccharide response in murine macrophages.
    9. The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.
      Title: The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis.
    10. Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy.
      Title: Down-regulation of HuR inhibits pathological angiogenesis in oxygen-induced retinopathy.
    Submit: New GeneRIF Correction See all GeneRIFs (140)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (10)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables lncRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lncRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables mRNA 3'-UTR AU-rich region binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables miRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in 3'-UTR-mediated mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA destabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA destabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of miRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of superoxide anion generation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of superoxide anion generation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in post-transcriptional gene silencing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasmic vesicle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sarcoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ELAV-like protein 1
    Names
    ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
    ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
    HU-antigen A
    elav-like generic protein
    hu-antigen R
    melG

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010485.3 → NP_034615.2  ELAV-like protein 1

      See identical proteins and their annotated locations for NP_034615.2

      Status: VALIDATED

      Source sequence(s)
      AC155164, AK028769, AK080365, BB305633, BY775007
      Consensus CDS
      CCDS22084.1
      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Related
      ENSMUSP00000096549.5, ENSMUST00000098950.6
      Conserved Domains (1) summary
      TIGR01661
      Location:19 → 326
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      4334781..4375104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508698.5 → XP_006508761.1  ELAV-like protein 1 isoform X1

      See identical proteins and their annotated locations for XP_006508761.1

      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Conserved Domains (1) summary
      TIGR01661
      Location:19 → 326
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    2. XM_030243302.2 → XP_030099162.1  ELAV-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Conserved Domains (1) summary
      TIGR01661
      Location:19 → 326
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    3. XM_030243301.2 → XP_030099161.1  ELAV-like protein 1 isoform X1

      UniProtKB/Swiss-Prot
      P70372, Q60745, Q78QY3
      UniProtKB/TrEMBL
      Q3UFF9, Q8BM84, Q8BW03
      Related
      ENSMUSP00000146866.2, ENSMUST00000209010.2
      Conserved Domains (1) summary
      TIGR01661
      Location:19 → 326
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70372.2 GenPept UniProtKB/Swiss-Prot:P70372

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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