Macrod2 mono-ADP ribosylhydrolase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Macrod2provided by MGI
Official Full Name: mono-ADP ribosylhydrolase 2provided by MGI
Primary source: MGI:MGI:1920149
See related: Ensembl:ENSMUSG00000068205 AllianceGenome:MGI:1920149
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110033L15Rik; 2610107G07Rik; 2900006F19Rik
Summary: Predicted to enable ADP-ribosylglutamate hydrolase activity and deacetylase activity. Involved in brain development. Acts upstream of or within response to bacterium. Predicted to be located in nucleolus. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; muscle tissue; and sensory organ. Orthologous to human MACROD2 (mono-ADP ribosylhydrolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E18 (RPKM 2.9), frontal lobe adult (RPKM 2.4) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F3- G1; 2 69.2 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (140237223..142234886)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (140395303..142392966)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
Title: Behavioural Characterisation of Macrod1 and Macrod2 Knockout Mice.
MacroD2 is expressed and may have a physiological role in the central nervous system during brain development
Title: Biochemical and Morphological Characterization of a Neurodevelopmental Disorder-Related Mono-ADP-Ribosylhydrolase, MACRO Domain Containing 2.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3)

General gene information

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Markers

D2Mit166 (e-PCR), detects polymorphism
- UniSTS:129030

MT465 (e-PCR)
- UniSTS:129031

fk57e05.x1 (e-PCR)
- UniSTS:201226

D2Mit401 (e-PCR), detects polymorphism
- UniSTS:129305

mHAa57d2.seq (e-PCR)
- UniSTS:125991

BB462515 (e-PCR)
- UniSTS:207410

D2Mit422 (e-PCR), detects polymorphism
- UniSTS:129330

D2Mit212 (e-PCR), detects polymorphism
- UniSTS:129087

Macrod2 (e-PCR), detects polymorphism
- UniSTS:532336

RH118254 (e-PCR)
- UniSTS:160923

D2Mit526 (e-PCR), detects polymorphism
- UniSTS:129442

D2Mit526.1 (e-PCR), detects polymorphism
- UniSTS:129443

D2Mit526.2 (e-PCR), detects polymorphism
- UniSTS:129444

AU015093 (e-PCR)
- UniSTS:167338

D2Mit308 (e-PCR), detects polymorphism
- UniSTS:129198

D2Dcr85 (e-PCR), detects polymorphism
- UniSTS:507644

D2Dcr86 (e-PCR), detects polymorphism
- UniSTS:507645

D2Dcr87 (e-PCR), detects polymorphism
- UniSTS:507646

D2Dcr88 (e-PCR), detects polymorphism
- UniSTS:507647

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-ribosylglutamate hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-ribosylglutamate hydrolase activity	ISO Inferred from Sequence Orthology more info
enables ADP-ribosylglutamate hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables deacetylase activity	IEA Inferred from Electronic Annotation more info
enables deacetylase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on glycosyl bonds	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on glycosyl bonds	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in brain development	IEP Inferred from Expression Pattern more info	PubMed
involved_in peptidyl-glutamate ADP-deribosylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-glutamate ADP-deribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein de-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein de-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in purine nucleoside metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine nucleoside metabolic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleoside metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-ribose glycohydrolase MACROD2

Names: MACRO domain containing 2; MACRO domain-containing protein 2; O-acetyl-ADP-ribose deacetylase MACROD2; [Protein ADP-ribosylaspartate] hydrolase MACROD2; [Protein ADP-ribosylglutamate] hydrolase; [Protein ADP-ribosylglutamate] hydrolase MACROD2

NP_001013824.2

EC 3.2.2.-

EC 3.5.1.-

NP_001393313.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393314.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393315.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393316.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393317.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393318.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393319.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393320.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393321.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393322.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393323.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393324.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393325.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393326.1

EC 3.2.2.-

EC 3.5.1.-

NP_001393327.1

EC 3.2.2.-

EC 3.5.1.-

NP_082663.1

EC 3.2.2.-

EC 3.5.1.-

XP_006500314.1

EC 3.2.2.-

EC 3.5.1.-

XP_006500316.1

EC 3.2.2.-

EC 3.5.1.-

XP_011238096.1

EC 3.2.2.-

EC 3.5.1.-

XP_017174774.1

EC 3.2.2.-

EC 3.5.1.-

XP_036018502.1

EC 3.2.2.-

EC 3.5.1.-

XP_036018504.1

EC 3.2.2.-

EC 3.5.1.-

XP_036018505.1

EC 3.2.2.-

EC 3.5.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013802.4 → NP_001013824.2 ADP-ribose glycohydrolase MACROD2 isoform 1

See identical proteins and their annotated locations for NP_001013824.2

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

Consensus CDS

CCDS50733.1

UniProtKB/Swiss-Prot

Q3UYG8

UniProtKB/TrEMBL

A2AS33

Related

ENSMUSP00000105691.2, ENSMUST00000110064.8

Conserved Domains (2) summary

COG2110
Location:70 → 239

YmdB; O-acetyl-ADP-ribose deacetylase (regulator of RNase III), contains Macro domain [Translation, ribosomal structure and biogenesis]

cd02908
Location:71 → 237

Macro_Appr_pase_like; Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...
NM_001406384.1 → NP_001393313.1 ADP-ribose glycohydrolase MACROD2 isoform 3

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406385.1 → NP_001393314.1 ADP-ribose glycohydrolase MACROD2 isoform 4

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406386.1 → NP_001393315.1 ADP-ribose glycohydrolase MACROD2 isoform 5

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406387.1 → NP_001393316.1 ADP-ribose glycohydrolase MACROD2 isoform 6

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406388.1 → NP_001393317.1 ADP-ribose glycohydrolase MACROD2 isoform 7

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406389.1 → NP_001393318.1 ADP-ribose glycohydrolase MACROD2 isoform 8

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406390.1 → NP_001393319.1 ADP-ribose glycohydrolase MACROD2 isoform 9

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406391.1 → NP_001393320.1 ADP-ribose glycohydrolase MACROD2 isoform 10

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406392.1 → NP_001393321.1 ADP-ribose glycohydrolase MACROD2 isoform 11

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406393.1 → NP_001393322.1 ADP-ribose glycohydrolase MACROD2 isoform 12

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443

Related

ENSMUSP00000105694.2, ENSMUST00000110067.8
NM_001406394.1 → NP_001393323.1 ADP-ribose glycohydrolase MACROD2 isoform 13

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL928823, AL929027, AL929443
NM_001406395.1 → NP_001393324.1 ADP-ribose glycohydrolase MACROD2 isoform 14

Status: VALIDATED

Source sequence(s)

AL731795, AL837516, AL844562, AL844582, AL845530, AL929027, AL929443
NM_001406396.1 → NP_001393325.1 ADP-ribose glycohydrolase MACROD2 isoform 15

Status: VALIDATED

Source sequence(s)

AL731795, AL928700, AL929027

UniProtKB/TrEMBL

B1AW12

Related

ENSMUSP00000105690.2, ENSMUST00000110063.8
NM_001406397.1 → NP_001393326.1 ADP-ribose glycohydrolase MACROD2 isoform 16

Status: VALIDATED

Source sequence(s)

AL731795, AL928700, AL929027

Related

ENSMUST00000154505.8
NM_001406398.1 → NP_001393327.1 ADP-ribose glycohydrolase MACROD2 isoform 17

Status: VALIDATED

Source sequence(s)

AL731795, AL928700, AL929027
NM_028387.2 → NP_082663.1 ADP-ribose glycohydrolase MACROD2 isoform 2

See identical proteins and their annotated locations for NP_082663.1

Status: VALIDATED

Source sequence(s)

AL731795

Consensus CDS

CCDS16805.1

UniProtKB/TrEMBL

Q9D117

Related

ENSMUSP00000041780.8, ENSMUST00000043836.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

140237223..142234886

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162611.1 → XP_036018504.1 ADP-ribose glycohydrolase MACROD2 isoform X14

UniProtKB/TrEMBL

A2AS33

Conserved Domains (1) summary

cd02908
Location:71 → 237

Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family
XM_006500251.3 → XP_006500314.1 ADP-ribose glycohydrolase MACROD2 isoform X11

UniProtKB/TrEMBL

A2AS33

Conserved Domains (2) summary

COG5271
Location:243 → 430

MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]

PRK00431
Location:71 → 239

PRK00431; ADP-ribose-binding protein
XM_011239794.2 → XP_011238096.1 ADP-ribose glycohydrolase MACROD2 isoform X8

UniProtKB/TrEMBL

A2AS33

Conserved Domains (1) summary

cl00019
Location:71 → 200

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_036162609.1 → XP_036018502.1 ADP-ribose glycohydrolase MACROD2 isoform X9

UniProtKB/TrEMBL

A2AS33

Conserved Domains (2) summary

cd02908
Location:71 → 198

Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

NF033845
Location:289 → 430

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_036162612.1 → XP_036018505.1 ADP-ribose glycohydrolase MACROD2 isoform X16

UniProtKB/TrEMBL

A2AS33

Conserved Domains (2) summary

cd02908
Location:71 → 198

Macro_OAADPr_deacetylase; macrodomain, O-acetyl-ADP-ribose (OAADPr) family

NF033845
Location:205 → 417

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_017319285.2 → XP_017174774.1 ADP-ribose glycohydrolase MACROD2 isoform X13

UniProtKB/TrEMBL

A2AS33

Conserved Domains (1) summary

cl00019
Location:70 → 189

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...
XM_006500253.3 → XP_006500316.1 ADP-ribose glycohydrolase MACROD2 isoform X15

Related

ENSMUST00000138786.2

Conserved Domains (1) summary

cl00019
Location:42 → 184

Macro; Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly ...