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    Sdhaf1 succinate dehydrogenase complex assembly factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 68332, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sdhaf1provided by MGI
    Official Full Name
    succinate dehydrogenase complex assembly factor 1provided by MGI
    Primary source
    MGI:MGI:1915582
    See related
    Ensembl:ENSMUSG00000074211 AllianceGenome:MGI:1915582
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lyrm8; 0610010E21Rik
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrion. Is expressed in several structures, including brain; genitourinary system; gut gland; large intestine; and thymus. Human ortholog(s) of this gene implicated in mitochondrial complex II deficiency. Orthologous to human SDHAF1 (succinate dehydrogenase complex assembly factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See Sdhaf1 in Genome Data Viewer
    Location:
    7 B1; 7 17.39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30020834..30021800, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30321409..30322375, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3711 Neighboring gene alkB homolog 6 Neighboring gene spectrin repeat containing, nuclear envelope family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E1730 Neighboring gene STARR-positive B cell enhancer ABC_E3712 Neighboring gene RIKEN cDNA 4930479H17 gene Neighboring gene predicted gene, 25259 Neighboring gene leucine rich repeat and fibronectin type III domain containing 3

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex II assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial respiratory chain complex II assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrial respiratory chain complex II assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    succinate dehydrogenase assembly factor 1, mitochondrial
    Names
    LYR motif-containing protein 8
    SDH assembly factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033140.3NP_001028312.2  succinate dehydrogenase assembly factor 1, mitochondrial

      See identical proteins and their annotated locations for NP_001028312.2

      Status: VALIDATED

      Source sequence(s)
      AA050643, AA266979, CA451543
      Consensus CDS
      CCDS39881.1
      UniProtKB/Swiss-Prot
      B2RVF8, Q3U276
      Related
      ENSMUSP00000096185.4, ENSMUST00000098586.5
      Conserved Domains (1) summary
      pfam13232
      Location:965
      Complex1_LYR_1; Complex1_LYR-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30020834..30021800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)