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    Dcaf12l1 DDB1 and CUL4 associated factor 12-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 245404, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dcaf12l1provided by MGI
    Official Full Name
    DDB1 and CUL4 associated factor 12-like 1provided by MGI
    Primary source
    MGI:MGI:2444462
    See related
    Ensembl:ENSMUSG00000045284 AllianceGenome:MGI:2444462
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wdr40b; Decaf12l1; 9330180J20; A230038L21Rik
    Summary
    Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Is expressed in extraembryonic ectoderm; follicle cell of primordial follicle; and ovary. Orthologous to human DCAF12L1 (DDB1 and CUL4 associated factor 12 like 1) and DCAF12L2 (DDB1 and CUL4 associated factor 12 like 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in frontal lobe adult (RPKM 6.9), cortex adult (RPKM 6.6) and 20 other tissues See more
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    Genomic context

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    See Dcaf12l1 in Genome Data Viewer
    Location:
    X A4; X 24.0 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (43875444..43879074, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (44786567..44790197, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47080 Neighboring gene inosine triphosphatase (nucleoside triphosphate pyrophosphatase) pseudogene 3 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47081 Neighboring gene STARR-seq mESC enhancer starr_47082 Neighboring gene SEC13 homolog pseudogene Neighboring gene proline rich 32

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice. Houston BJ, et al. Dev Biol, 2022 Oct. PMID 35850260
    2. Ectopic expression of DNA methyltransferases DNMT3A2 and DNMT3L leads to aberrant hypermethylation and postnatal lethality in mice. Sasaki K, et al. Mol Reprod Dev, 2019 Jun. PMID 30834655, Free PMC Article
    3. Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression. Pearton DJ, et al. Dev Biol, 2014 Aug 15. PMID 24859262
    4. Genomewide discovery and classification of candidate ovarian fertility genes in the mouse. Gallardo TD, et al. Genetics, 2007 Sep. PMID 17660561, Free PMC Article
    5. Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network. Shalom-Barak T, et al. Dev Biol, 2012 Dec 1. PMID 22967998, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice.
      Title: DDB1- and CUL4-associated factor 12-like protein 1 (Dcaf12l1) is not essential for male fertility in mice.
    2. Transcripts highly enriched in ovary; gene identified as candidate female fertility factor.
      Title: Genomewide discovery and classification of candidate ovarian fertility genes in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DDB1- and CUL4-associated factor 12-like protein 1
    Names
    WD repeat domain 40B
    WD repeat-containing protein 40B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190718.1 → NP_001177647.1  DDB1- and CUL4-associated factor 12-like protein 1

      See identical proteins and their annotated locations for NP_001177647.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (B) differs in the 3' UTR compared to variant A. Both variants A and B encode the same protein.
      Source sequence(s)
      AK038557, AK047360, AL670238, BB337276
      Consensus CDS
      CCDS30101.1
      UniProtKB/Swiss-Prot
      Q6NV47, Q8C8E2, Q8CA30, Q8CAL3, Q8CBW4, Q8CBX8
      Related
      ENSMUSP00000110708.2, ENSMUST00000115056.2
      Conserved Domains (2) summary
      COG2319
      Location:190 → 428
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:138 → 180
      7WD40; WD40 repeat [structural motif]

    2. NM_178739.6 → NP_848854.3  DDB1- and CUL4-associated factor 12-like protein 1

      See identical proteins and their annotated locations for NP_848854.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (A) represents the longer transcript. Both variants A and B encode the same protein.
      Source sequence(s)
      AK034472, AK038557, AL670238, BB337276
      Consensus CDS
      CCDS30101.1
      UniProtKB/Swiss-Prot
      Q6NV47, Q8C8E2, Q8CA30, Q8CAL3, Q8CBW4, Q8CBX8
      Related
      ENSMUSP00000062991.3, ENSMUST00000060481.9
      Conserved Domains (2) summary
      COG2319
      Location:190 → 428
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:138 → 180
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      43875444..43879074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CBW4.1 GenPept UniProtKB/Swiss-Prot:Q8CBW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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