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    Zfp770 zinc finger protein 770 [ Mus musculus (house mouse) ]

    Gene ID: 228491, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp770provided by MGI
    Official Full Name
    zinc finger protein 770provided by MGI
    Primary source
    MGI:MGI:2445100
    See related
    Ensembl:ENSMUSG00000040321 AllianceGenome:MGI:2445100
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf770; 6430601A21Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in cerebral cortex ventricular layer; cortical plate; early conceptus; and secondary oocyte. Orthologous to human ZNF770 (zinc finger protein 770). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 3.5), cerebellum adult (RPKM 2.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp770 in Genome Data Viewer
    Location:
    2 E4; 2 57.61 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (114023937..114031945, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (114193456..114201432, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54143 Neighboring gene VISTA enhancer mm182 Neighboring gene STARR-positive B cell enhancer mm9_chr2:113971248-113971549 Neighboring gene aquarius Neighboring gene STARR-positive B cell enhancer ABC_E1593 Neighboring gene STARR-seq mESC enhancer starr_05403 Neighboring gene microRNA 7002 Neighboring gene STARR-seq mESC enhancer starr_05404 Neighboring gene STARR-seq mESC enhancer starr_05405 Neighboring gene STARR-seq mESC enhancer starr_05406 Neighboring gene STARR-seq mESC enhancer starr_05407 Neighboring gene STARR-seq mESC enhancer starr_05408 Neighboring gene STARR-seq mESC enhancer starr_05409 Neighboring gene predicted gene, 31146 Neighboring gene STARR-seq mESC enhancer starr_05410 Neighboring gene predicted gene, 54144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CPEB3 Maintains Developmental Competence of the Oocyte. Lamacova L, et al. Cells, 2024 May 16. PMID 38786074, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 770

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175466.5 → NP_780675.1  zinc finger protein 770

      See identical proteins and their annotated locations for NP_780675.1

      Status: VALIDATED

      Source sequence(s)
      AL844569
      Consensus CDS
      CCDS16566.1
      UniProtKB/Swiss-Prot
      Q3TPP6, Q8BIQ8, Q8BK15, Q8BLQ1
      UniProtKB/TrEMBL
      B2RPX9
      Related
      ENSMUSP00000052194.4, ENSMUST00000050668.4
      Conserved Domains (2) summary
      sd00017
      Location:166 → 186
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:500 → 524
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      114023937..114031945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161339.1 → XP_036017232.1  zinc finger protein 770 isoform X1

      UniProtKB/Swiss-Prot
      Q3TPP6, Q8BIQ8, Q8BK15, Q8BLQ1
      UniProtKB/TrEMBL
      B2RPX9
      Conserved Domains (2) summary
      sd00017
      Location:166 → 186
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:500 → 524
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIQ8.1 GenPept UniProtKB/Swiss-Prot:Q8BIQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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