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    Cdc34 cell division cycle 34 [ Mus musculus (house mouse) ]

    Gene ID: 216150, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdc34provided by MGI
    Official Full Name
    cell division cycle 34provided by MGI
    Primary source
    MGI:MGI:102657
    See related
    Ensembl:ENSMUSG00000020307 AllianceGenome:MGI:102657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    UBE2R1; E2-CDC34
    Summary
    Enables ubiquitin conjugating enzyme activity. Predicted to be involved in several processes, including cellular response to interferon-beta; negative regulation of cAMP-mediated signaling; and protein ubiquitination. Predicted to be located in cytosol and nuclear speck. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human CDC34 (cell division cycle 34, ubiqiutin conjugating enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 167.9), placenta adult (RPKM 79.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cdc34 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (79518029..79524232)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (79682193..79688398)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mucosal vascular addressin cell adhesion molecule 1 Neighboring gene STARR-positive B cell enhancer ABC_E8346 Neighboring gene tubulin polyglutamylase complex subunit 1 Neighboring gene STARR-positive B cell enhancer ABC_E3896 Neighboring gene granzyme M (lymphocyte met-ase 1) Neighboring gene predicted gene, 25794

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin conjugating enzyme activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin conjugating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 R1
    Names
    (E3-independent) E2 ubiquitin-conjugating enzyme R1
    E2 ubiquitin-conjugating enzyme R1
    cell division cycle 34 homolog
    ubiquitin-conjugating enzyme Cdc34
    ubiquitin-conjugating enzyme E2-32 kDa complementing
    ubiquitin-conjugating enzyme E2-CDC34
    ubiquitin-protein ligase R1
    NP_001346746.1
    NP_001346747.1
    NP_808281.1
    XP_017169376.1
    XP_017169377.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359817.1NP_001346746.1  ubiquitin-conjugating enzyme E2 R1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151828, BE988402, BY083281, BY114161, CA320111
      Consensus CDS
      CCDS88049.1
      UniProtKB/TrEMBL
      A0A1W2P7U1
      Related
      ENSMUSP00000151763.2, ENSMUST00000219791.2
      Conserved Domains (1) summary
      cd00195
      Location:11125
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001359818.1NP_001346747.1  ubiquitin-conjugating enzyme E2 R1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC151828, BE988402, BY114161, CA320111, CX210748
      UniProtKB/TrEMBL
      A0A1W2P7U9
      Related
      ENSMUSP00000152000.2, ENSMUST00000218964.2
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_177613.2NP_808281.1  ubiquitin-conjugating enzyme E2 R1 isoform 1

      See identical proteins and their annotated locations for NP_808281.1

      Status: VALIDATED

      Source sequence(s)
      BC039160
      Consensus CDS
      CCDS23983.1
      UniProtKB/Swiss-Prot
      Q505K8, Q8CFI2
      UniProtKB/TrEMBL
      A0A087WP01
      Related
      ENSMUSP00000020550.6, ENSMUST00000020550.13
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      79518029..79524232
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313888.3XP_017169377.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/Swiss-Prot
      Q505K8, Q8CFI2
      UniProtKB/TrEMBL
      A0A087WP01
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. XM_017313887.2XP_017169376.1  ubiquitin-conjugating enzyme E2 R1 isoform X1

      UniProtKB/Swiss-Prot
      Q505K8, Q8CFI2
      UniProtKB/TrEMBL
      A0A087WP01
      Conserved Domains (1) summary
      cd00195
      Location:11162
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...